Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and
type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism …

Diabetes is a disease characterized by a relative or absolute lack of insulin, leading to
hyperglycaemia. There are two main types of diabetes: type 1 diabetes and type 2 diabetes …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Diabetes mellitus type 1 and 2 (T1DM and T2DM) are complex multifactorial diseases. Loss
of beta-cell function caused by reduced secretory capacity and enhanced apoptosis is a key …

Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) are anti-diabetes/obesity hormones
secreted from the gut after meal ingestion. We have shown that dietary-resistant starch (RS) …

Diabetes mellitus is a lifelong, metabolic disease that is characterised by an inability to
maintain normal glucose homeostasis. There are several different forms of diabetes …

Abstract Activating transcription factor 3 (ATF3) is a stress-inducible gene and encodes a
member of the ATF/CREB family of transcription factors. However, the physiological …

Death of pancreatic β cells is a pathological hallmark of type 1 diabetes (T1D). However, the
molecular mechanisms of β cell death and its regulation are poorly understood. Here we …

Type 1 diabetes is characterized by the infiltration of inflammatory cells into pancreatic islets
of Langerhans, followed by the selective and progressive destruction of insulin-secreting …

The transcription factor Nrf2 regulates the expression of antioxidant genes. Hyperglycemia‐
induced oxidative stress is involved in the pathogenesis of diabetes and its complications …