Efficiency and development of guanidine chelate catalysts for rapid and green synthesis of 7‐amino‐4,5‐dihydro‐tetrazolo[1,5‐a]pyrimidine‐6‐carbonitrile derivatives …

MAEAAA El‐Remaily, T El‐Dabea… - Applied …, 2023 - Wiley Online Library
Three GUBZCu, GUBZVO, and GUBZPd chelates have been prepared from 2‐guanidino
benzimidazole (GUBZ ligand) by a bidentate coordinating approach. FT‐IR, mass, and NMR …

Synthesis, characterization, and DFT study of linear and non-linear optical properties of some novel thieno [2, 3-b] thiophene azo dye derivatives

EK Shokr, MS Kamel, H Abdel-Ghany… - Materials Chemistry and …, 2022 - Elsevier
Abstract Some novel thieno [2, 3-b] thiophene-2, 5-dicarbonitrile derivatives namely; 3, 4-bis
(2-hydroxynaphthalen-1-yl) diazenyl) thieno [2, 3-b] thiophene-2, 5-dicarbonitrile, 3, 4-bis (4 …

[HTML][HTML] Screening a panel of topical ophthalmic medications against MMP-2 and MMP-9 to investigate their potential in keratoconus management

A Belal, MA Elanany, EY Santali, AA Al-Karmalawy… - Molecules, 2022 - mdpi.com
Keratoconus (KC) is a serious disease that can affect people of any race or nationality,
although the exact etiology and pathogenic mechanism are still unknown. In this study, thirty …

Design and evaluation of sulfadiazine derivatives as potent dual inhibitors of EGFR WT and EGFR T790M: integrating biological, molecular docking, and ADMET …

HM Abd El-Lateef, HAA Ezelarab, AM Ali, AT Alsaggaf… - RSC …, 2024 - pubs.rsc.org
A series of derivatives (5–14) were synthesized through the diazotization of sulfadiazine with
active methylene compounds. The chemical structures of these newly designed compounds …

Thieno[2,3-b]thiophene Derivatives as Potential EGFRWT and EGFRT790M Inhibitors with Antioxidant Activities: Microwave-Assisted Synthesis and Quantitative In …

SA Ahmed, MS Kamel, MO Aboelez, X Ma… - ACS …, 2022 - ACS Publications
Microwave-assisted synthesis and spectral analysis of certain novel derivatives of 3, 4-
diaminothieno [2, 3-b] thiophene-2, 5-dicarbonitrile 1–7 were carried out. Compounds 1–7 …

Tailoring of rosuvastatin calcium and atenolol bilayer tablets for the management of hyperlipidemia associated with hypertension: a preclinical study

MMA Elsayed, MO Aboelez, MS Mohamed… - Pharmaceutics, 2022 - mdpi.com
Hyperlipidemia is still the leading cause of heart disease in patients with hypertension. The
purpose of this study is to make rosuvastatin calcium (ROS) and atenolol (AT) bilayer tablets …

Small Molecules as Anti‐inflammatory Agents: Molecular Mechanisms and Heterocycles as Inhibitors of Signaling Pathways

NJ Basha - ChemistrySelect, 2023 - Wiley Online Library
Cancer and inflammation interlink with many pathways. Millions of people died because of
these two disorders. Major pathways that cause both inflammation and cancer are STAT3 …

Green synthesis design, spectroscopic characterizations, and biological activities of novel pyrrole derivatives: an application to evaluate their toxic effect on cotton …

MS Kamel, MO Aboelez, MR Elnagar… - …, 2022 - Wiley Online Library
Green synthesis design and spectroscopic characterizations of novel pyrrole derivatives (1–
6) with insecticidal bioefficacy have been achieved. The toxic effect using a leaf dip bioassay …

[HTML][HTML] Development and optimization of vildagliptin solid lipid nanoparticles loaded ocuserts for controlled ocular delivery: A promising approach towards treating …

MMA Elsayed, A Elsayed, MA Fouad… - International Journal of …, 2024 - Elsevier
Diabetes mellitus (DM) is the most prevalent cause of diabetic retinopathy (DRP). DRP has
been recognized for a long time as a microvascular disease. Many drugs were used to treat …

Microwave-assisted synthesis, spectroscopic characterization, and biological evaluation of fused thieno[2,3-d]pyrimidines as potential anti-cancer agents targeting EGFRWT and …

MO Aboelez, MS Kamel, A Belal… - Molecular Diversity, 2023 - Springer
Epidermal growth factor receptor (EGFR) is a transmembrane protein tyrosine kinase that is
usually overexpressed in many types of cancers. In the present study, an effort was done in …