Infectious diseases like malaria, tuberculosis or HIV are among the leading causes of death
worldwide according to WHO estimations. Nevertheless, the fight against infectious diseases …

Toxoplasma gondii severely threaten the health of immunocompromised patients and
pregnant women as this parasite can cause several disease, including brain and eye …

Toxoplasmosis is a common parasitic disease caused by Toxoplasma gondii. Limitations of
available treatments motivate the search for better therapies for toxoplasmosis. In this study …

Past researches on 4-thiazolidinone nucleus have revealed the prominent potential of
derivatives containing this nucleus to be developed as a potent therapeutic agent. Because …

A structure activity relationship (SAR) study of a library of 56 compounds (54 ruthenium and
2 osmium derivatives) based on the trithiolato-bridged dinuclear ruthenium (II)-arene …

Thiazolidin-4-one derivatives have a wide range of therapeutic implementations and clinical
significance for medicinal chemistry. This heterocyclic ring has been reported to possess a …

Treatments for toxoplasmosis such as pyrimethamine have shown numerous side effects. It
has been reported that the likelihood of relapse associated with pyrimethamine-based …

Abstract A series of thiopyrano [2, 3-d] thiazole derivatives via Michael reaction of
malononitrile and 5-arylideneisorhodanine were synthesized. The further acid or alkaline …

Toxoplasmosis is the parasitic infection caused by the obligate intracellular parasite T.
gondii. This pathogen possesses three different stages of life, namely (1) sporozoites,(2) …

Background Thiazolidinone derivatives show inhibitory activity (IC 50) against the
Toxoplasma gondii parasite, as well as high selectivity with high therapeutic index. To …