Pathology and pathobiology of pulmonary hypertension: current insights and future directions

C Guignabert, J Aman, S Bonnet… - European …, 2024 - publications.ersnet.org
In recent years, major advances have been made in the understanding of the cellular and
molecular mechanisms driving pulmonary vascular remodelling in various forms of …

Differentiation and regulation of CD4+ T cell subsets in Parkinson's disease

X Sun, R Gu, J Bai - Cellular and Molecular Life Sciences, 2024 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disease, and its
hallmark pathological features are the loss of dopaminergic (DA) neurons in the midbrain …

Role of Treg cell subsets in cardiovascular disease pathogenesis and potential therapeutic targets

Y Xia, D Gao, X Wang, B Liu, X Shan, Y Sun… - Frontiers in …, 2024 - frontiersin.org
In the genesis and progression of cardiovascular diseases involving both innate and
adaptive immune responses, inflammation plays a pivotal and dual role. Studies in …

IRF4 affects the protective effect of regulatory T cells on the pulmonary vasculature of a bronchopulmonary dysplasia mouse model by regulating FOXP3

Y Zhu, L He, Y Zhu, H Yao, J Jiang, H Lu - Molecular Medicine, 2024 - Springer
Background Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in
preterm infants, characterised by compromised alveolar development and pulmonary …

[HTML][HTML] Histone deacetylases facilitate Th17-cell differentiation and pathogenicity in autoimmune uveitis via CDK6/ID2 axis

C Zhang, X Liu, C Gu, Y Su, J Lv, Y Liu, Y Gao… - Journal of Advanced …, 2024 - Elsevier
Introduction Autoimmune uveitis (AU) is a prevalent ocular autoimmune disease leading to
significant visual impairment. However, underlying pathogenesis of AU required to develop …

PD-1+ T lymphocyte proportions and hospitalized exacerbation of COPD: a prospective cohort study

H Xue, X Lan, T Xue, X Tang, H Yang, Z Hu, N Xu… - Respiratory …, 2024 - Springer
Objective To evaluate the predictive value of PD-1 expression in T lymphocytes for
rehospitalization due to acute exacerbations of COPD (AECOPD) in discharged patients …

Regulatory T Cells: Supporting Lung Homeostasis and Promoting Resolution and Repair after Lung Injury

MJ McCullough, PG Bose, JR Mock - The International Journal of …, 2024 - Elsevier
Regulatory T cells, characterized by their expression of the transcription factor Forkhead box
P3, are indispensable in maintaining immune homeostasis. The respiratory system is …

Identification of an immune-related gene panel for the diagnosis of pulmonary arterial hypertension using bioinformatics and machine learning

P Xiong, Q Huang, Y Mao, H Qian, Y Yang… - International …, 2025 - Elsevier
Objective This study aimed to screen an immune-related gene (IRG) panel and develop a
novel approach for diagnosing pulmonary arterial hypertension (PAH) utilizing …

Viewing Pulmonary Arterial Hypertension Pathogenesis and Opportunities for Disease-Modifying Therapy Through the Lens of Biomass

ML Steinhauser, BA Maron - Basic to Translational Science, 2024 - jacc.org
Fibroproliferative remodeling of distal pulmonary arterioles is a cornerstone characteristic of
pulmonary arterial hypertension (PAH). Data from contemporary quantitative imaging …

Regulating the Regulators: Epigenetic Modulation of Regulatory T Cells in Pulmonary Hypertension

S Farha, MA Aldred - American Journal of Respiratory and Critical …, 2023 - atsjournals.org
Pulmonary hypertension (PH) is characterized by significant vascular remodeling and
persistent inflammation. Inflammatory cells, including monocyte, macrophages, dendritic …