Dual COX-2/15-LOX inhibitors: A new avenue in the prevention of cancer
A Aliabadi, E Khanniri, M Mahboubi-Rabbani… - European journal of …, 2023 - Elsevier
Abstract Dual cyclooxygenase 2/15-lipoxygenase inhibitors constitute a valuable alternative
to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …
to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …
Synthesis and evaluation of 1, 3, 5-triaryl-2-pyrazoline derivatives as potent dual inhibitors of urease and α-glucosidase together with their cytotoxic, molecular …
In the present work, a concise library of 1, 3, 5-triaryl-2-pyrazolines (2a–2q) was designed
and synthesized by employing a multistep strategy, and the newly synthesized compounds …
and synthesized by employing a multistep strategy, and the newly synthesized compounds …
Molecular hybrids of substituted phenylcarbamoylpiperidine and 1, 2, 4-triazole methylacetamide as potent 15-LOX inhibitors: Design, synthesis, DFT calculations and …
Inflammation is a multifaceted phenomenon triggered by potentially active mediators acutely
released arachidonic acid metabolites partially in lipoxygenase (LOX) pathway which are …
released arachidonic acid metabolites partially in lipoxygenase (LOX) pathway which are …
Assessing p-tolyloxy-1, 3, 4-oxadiazole acetamides as lipoxygenase inhibitors assisted by in vitro and in silico studies
The underlying correlation between the inflammation, innate immunity and cancer is
extensively familiar and linked through a process mediated by three enzymes; …
extensively familiar and linked through a process mediated by three enzymes; …
Synthesis, in Vitro Cholinesterase Inhibition, Molecular Docking, DFT, and ADME Studies of Novel 1,3,4‐Oxadiazole‐2‐Thiol Derivatives
Abstract A series of 1, 3, 4‐oxadiazole‐2‐thiol derivatives bearing various alkyl or aryl
moieties were designed, synthesized, and characterized using modern spectroscopic …
moieties were designed, synthesized, and characterized using modern spectroscopic …
Probing N-substituted 4-(5-mercapto-4-ethyl-4H-1, 2, 4-triazol-3-yl)-N-phenylpiperdine-1-carboxamides as potent 15-LOX inhibitors supported with ADME, DFT …
In our continuous efforts to find out leads against the enzyme 15-lipoxygenase (15-LOX), the
current study deals with the synthesis of a series of new N-alkyl/aralkyl/aryl derivatives of 2 …
current study deals with the synthesis of a series of new N-alkyl/aralkyl/aryl derivatives of 2 …
Design, synthesis, and pharmacological evaluation of indazole carboxamides of N-substituted pyrrole derivatives as soybean lipoxygenase inhibitors
V Lavrentaki, A Kousaxidis, P Theodosis-Nobelos… - Molecular Diversity, 2023 - Springer
In this paper, we attempted to develop a novel class of compounds against lipoxygenase, a
key enzyme in the biosynthesis of leukotrienes implicated in a series of inflammatory …
key enzyme in the biosynthesis of leukotrienes implicated in a series of inflammatory …
Exploring ibuprofen derivatives as α‐glucosidase and lipoxygenase inhibitors: Cytotoxicity and in silico studies
S Daud, OR Abid, A Sardar, S Abdullah… - Archiv der …, 2022 - Wiley Online Library
This study reports the synthesis of a series of ibuprofen derivatives, including
thiosemicarbazides 4a–f, 1, 3, 4‐oxadiazoles 5a–f, 1, 3, 4‐thiadiazoles 6a–f, 1, 2, 4‐triazoles …
thiosemicarbazides 4a–f, 1, 3, 4‐oxadiazoles 5a–f, 1, 3, 4‐thiadiazoles 6a–f, 1, 2, 4‐triazoles …
Parsing p-tolyloxy-1, 3, 4-oxadiazolepropanamides as 15-lipoxygenase inhibitors prop up by in vitro and in silico profiling including structure determination
In humans, tissue injury result in the production of an inflammatory response and
arachidonic acid released from the damaged membrane phospholipids is oxidized in two …
arachidonic acid released from the damaged membrane phospholipids is oxidized in two …
Exploration of 4-tolyl-5-(p-tolyloxymethyl)-4H-1, 2, 4-triazole thioethers as potent 15-LOX inhibitors supported by in vitro, in silico, MD simulation and DNA binding …
Inflammation is an intricate process exacerbated by the sequential release of lipid mediators
during arachidonic acid metabolism through the LOX and COX pathways. The inhibition of …
during arachidonic acid metabolism through the LOX and COX pathways. The inhibition of …