Advances in multi-functional ligands and the need for metal-related pharmacology for the management of Alzheimer disease
Alzheimer's disease (AD) is the age linked neurodegenerative disorder with no disease
modifying therapy currently available. The available therapy only offers short term …
modifying therapy currently available. The available therapy only offers short term …
Advanced analytical methodologies in Alzheimer's disease drug discovery
Despite the constant progress in the understanding of the etiopathogenesis of Alzheimer's
disease (AD) over the last 50 years, just four long-standing drugs are currently used for AD …
disease (AD) over the last 50 years, just four long-standing drugs are currently used for AD …
Dynamic micellar oligomers of amyloid beta peptides play a crucial role in their aggregation mechanisms
A deep understanding of the early molecular mechanism of amyloid beta peptides (Aβ) is
crucial to develop therapeutic and preventive approaches for Alzheimer's disease (AD) …
crucial to develop therapeutic and preventive approaches for Alzheimer's disease (AD) …
Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease
Z Yang, Q Song, Z Cao, G Yu, Z Liu, Z Tan… - Bioorganic & Medicinal …, 2020 - Elsevier
A series of novel flurbiprofen-clioquinol hybrids were designed and synthesized as
multifunctional agents for Alzheimer's disease therapy, and their potential was evaluated …
multifunctional agents for Alzheimer's disease therapy, and their potential was evaluated …
Multi-target-based polypharmacology prediction (mTPP): an approach using virtual screening and machine learning for multi-target drug discovery
K Liu, X Chen, Y Ren, C Liu, T Lv, Y Zhang - Chemico-Biological …, 2022 - Elsevier
Polypharmacology has become a new paradigm in drug discovery and plays an
increasingly vital role in discovering multi-target drugs. In this context, multi-target drugs are …
increasingly vital role in discovering multi-target drugs. In this context, multi-target drugs are …
Copper(II)‐Catalyzed Direct Azidation of N‐Acylated 8‐Aminoquinolines by Remote C−H Activation
Y Dou, Z Xie, Z Sun, H Fang, C Shen, P Zhang… - …, 2016 - Wiley Online Library
Copper(II)‐Catalyzed Direct Azidation of N‐Acylated 8‐Aminoquinolines by Remote C−H
Activation - Dou - 2016 - ChemCatChem - Wiley Online Library Skip to Article Content Skip to …
Activation - Dou - 2016 - ChemCatChem - Wiley Online Library Skip to Article Content Skip to …
Identification of Multi-Target Anti-AD Chemical Constituents From Traditional Chinese Medicine Formulae by Integrating Virtual Screening and In Vitro Validation
B Zhang, J Zhao, Z Wang, P Guo, A Liu… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disease that seriously threatens the health
of the elderly. At present, no drugs have been proven to cure or delay the progression of the …
of the elderly. At present, no drugs have been proven to cure or delay the progression of the …
An iridium (III) complex as a photoactivatable tool for oxidation of amyloidogenic peptides with subsequent modulation of peptide aggregation
Aggregates of amyloidogenic peptides are involved in the pathogenesis of several
degenerative disorders. Herein, an iridium (III) complex, Ir‐1, is reported as a chemical tool …
degenerative disorders. Herein, an iridium (III) complex, Ir‐1, is reported as a chemical tool …
Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter‐Related Pathological Features in Alzheimer's Disease
HJ Lee, KJ Korshavn, Y Nam, J Kang… - … A European Journal, 2017 - Wiley Online Library
To elucidate the involvement of individual and inter‐related pathological factors [ie, amyloid‐
β (Aβ), metals, and oxidative stress] in the pathogenesis of Alzheimer's disease (AD) …
β (Aβ), metals, and oxidative stress] in the pathogenesis of Alzheimer's disease (AD) …
Room‐Temperature Dialkylamination of Chloroheteroarenes Using a Cu (II)/PTABS Catalytic System
The dimethylamino functionality has significant importance in industrially relevant molecules
and methodologies to install these efficiently are highly desirable. We report herein a highly …
and methodologies to install these efficiently are highly desirable. We report herein a highly …