The fatal, primarily childhood neurodegenerative disorders, neuronal ceroid lipofuscinoses
(NCLs), are currently associated with mutations in 13 genes. The protein products of these …

Neuronal ceroid lipofuscinoses (NCL) comprise a group of inherited lysosomal disorders
with variable age of onset, characterized by lysosomal accumulation of autofluorescent …

The NCLs (neuronal ceroid lipofuscinosis) are forms of neurodegenerative disease that
affect people of all ages and ethnicities but are most prevalent in children. Commonly known …

Hypoxic events are known to cause substantial damage to the hippocampus, cerebellum
and striatum. The impact of hypoxic shock on other brain parts is not sufficiently studied …

A causal contribution of hyperhomocysteinemia to cognitive decline and Alzheimer's
disease (AD), as well as potential prevention or mitigation of the pathology by dietary …

Tripeptidyl peptidase I (TPPI) is a lysosomal enzyme widely distributed in mammals and
humans. Its genetically determined deficiency causes the classical late-infantile form of …

Neuronal ceroid lipofuscinosis (NCL), also known as Batten disease, is a family of fatal,
autosomal recessive neurodegenerative lysosomal storage disorders, mostly of childhood …

A causal contribution of hyperhomocysteinemia to cognitive decline and Alzheimer's
disease (AD), as well as potential prevention or mitigation of the pathology by dietary …

The NCLs (neuronal ceroid lipofuscinosis) are forms of neurodegenerative disease that
affect people of all ages and ethnicities but are most prevalent in children. Commonly known …

Enzyme histochemical methods are valuable for the studies on the enzyme involvement in
different pathological processes. Here we describe two protocols for chromogenic and …