Generation of nanoscopic membrane curvature for membrane trafficking

MM Kozlov, JW Taraska - Nature reviews Molecular cell biology, 2023 - nature.com
Curved membranes are key features of intracellular organelles, and their generation
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …

Extracellular membrane vesicles in the three domains of life and beyond

S Gill, R Catchpole, P Forterre - FEMS microbiology reviews, 2019 - academic.oup.com
Cells from all three domains of life, Archaea, Bacteria and Eukarya, produce extracellular
vesicles (EVs) which are sometimes associated with filamentous structures known as …

Mechanical adaptability of tumor cells in metastasis

V Gensbittel, M Kräter, S Harlepp, I Busnelli, J Guck… - Developmental cell, 2021 - cell.com
The most dangerous aspect of cancer lies in metastatic progression. Tumor cells will
successfully form life-threatening metastases when they undergo sequential steps along a …

Dynamin, a membrane-remodelling GTPase

SM Ferguson, P De Camilli - Nature reviews Molecular cell biology, 2012 - nature.com
Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in
membrane remodelling, has a critical role in endocytic membrane fission events. The use of …

Microvesicles: mediators of extracellular communication during cancer progression

V Muralidharan-Chari, JW Clancy… - Journal of cell …, 2010 - journals.biologists.com
Microvesicles are generated by the outward budding and fission of membrane vesicles from
the cell surface. Recent studies suggest that microvesicle shedding is a highly regulated …

How proteins produce cellular membrane curvature

J Zimmerberg, MM Kozlov - Nature reviews Molecular cell biology, 2006 - nature.com
Biological membranes exhibit various function-related shapes, and the mechanism by which
these shapes are created is largely unclear. Here, we classify possible curvature-generating …

[HTML][HTML] A class of membrane proteins shaping the tubular endoplasmic reticulum

GK Voeltz, WA Prinz, Y Shibata, JM Rist, TA Rapoport - Cell, 2006 - cell.com
How is the characteristic shape of a membrane bound organelle achieved? We have used
an in vitro system to address the mechanism by which the tubular network of the …

Synaptic vesicle endocytosis

Y Saheki, P De Camilli - Cold Spring Harbor …, 2012 - cshperspectives.cshlp.org
Neurons can sustain high rates of synaptic transmission without exhausting their supply of
synaptic vesicles. This property relies on a highly efficient local endocytic recycling of …

Mechanisms of membrane curvature sensing

B Antonny - Annual review of biochemistry, 2011 - annualreviews.org
Bacteria and eukaryotic cells contain geometry-sensing tools in their cytosol: protein motifs
or domains that recognize the curvature, concave or convex, deep or shallow, of lipid …

How curved membranes recruit amphipathic helices and protein anchoring motifs

NS Hatzakis, VK Bhatia, J Larsen, KL Madsen… - Nature chemical …, 2009 - nature.com
Lipids and several specialized proteins are thought to be able to sense the curvature of
membranes (MC). Here we used quantitative fluorescence microscopy to measure curvature …