Central nervous system pharmacology of neuropeptide Y

JG Wettstein, B Earley, JL Junien - Pharmacology & therapeutics, 1995 - Elsevier
Neuropeptide Y (NPY) is a 36-amino acid peptide belonging to the pancreatic polypeptide
family that has marked and diverse biological activity across species. NPY originally was …

Creating the amylin story

TA Lutz - Appetite, 2022 - Elsevier
This paper is based on a presentation given at the Annual Meeting of the Society for the
Study of Ingestive Behavior in July 2021 and provides a personal view on some of the …

Differential permeability of the blood–brain barrier to two pancreatic peptides: insulin and amylin

WA Banks, AJ Kastin - Peptides, 1998 - Elsevier
Insulin and amylin are cosecreted by pancreatic B cells and have receptors within the
central nervous system (CNS), where they exert multiple effects. Although these peptides …

In vitro autoradiographic localization of amylin binding sites in rat brain

PM Sexton, G Paxinos, MA Kenney, PJ Wookey… - Neuroscience, 1994 - Elsevier
Amylin is a recently discovered 37 amino acid peptide which is co-secreted from the
pancreas with insulin and acts to modulate carbohydrate metabolism. Recently, high-affinity …

Amylin decreases meal size in rats

TA Lutz, N Geary, MM Szabady, E Del Prete… - Physiology & …, 1995 - Elsevier
Adult male rats were intraperitoneally (IP) injected with 1.0 μg/kg amylin at the beginning of
the dark phase in 24 h food deprived or undeprived rats, and a computerized system …

Permeability of the blood-brain barrier to amylin

WA Banks, AJ Kastin, LM Maness, W Huang… - Life sciences, 1995 - Elsevier
Amylin is co-secreted with insulin from the pancreas of patients with non-insulin dependent
diabetes mellitus, and its deposition may contribute to the central nervous system (CNS) …

Reduction of food intake in rats by intraperitoneal injection of low doses of amylin

TA Lutz, E Del Prete, E Scharrer - Physiology & behavior, 1994 - Elsevier
The effect of amylin injected IP on food intake in rats of different age (7–9 weeks, 3 months,
15–18 months) was investigated. The possible site of amylin action was investigated using …

Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state

IT Yonemoto, GJA Kroon, HJ Dyson, WE Balch… - Biochemistry, 2008 - ACS Publications
Human amylin, or islet amyloid polypeptide, is a peptide cosecreted with insulin by the beta
cells of the pancreatic islets of Langerhans. The 37-residue, C-terminally amidated human …

Stimulation of both aerobic glycolysis and Na+-K+-ATPase activity in skeletal muscle by epinephrine or amylin

JH James, KR Wagner, JK King… - American Journal …, 1999 - journals.physiology.org
Epinephrine and amylin stimulate glycogenolysis, glycolysis, and Na+-K+-ATPase activity in
skeletal muscle. However, it is not known whether these hormones stimulate glycolytic ATP …

Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan's enhancement of islet amyloid polypeptide (amylin) fibril formation.

GM Castillo, JA Cummings, W Yang, ME Judge… - Diabetes, 1998 - Am Diabetes Assoc
Islet amyloidosis is characterized by the deposition and accumulation of amylin in pancreatic
beta-cells and is observed in 90% of patients with type 2 diabetes. Previous studies have …