The first paper on “inflammaging” published in 2001 paved the way for a unifying theory on
how and why aging turns out to be the main risk factor for the development of the most …

Aim and objective Emerging translational evidence suggests that epigenetic alterations
(DNA methylation, miRNA expression, and histone modifications) occur after external stimuli …

Cardiometabolic disease is an increasing cause of morbidity and death in society. While M1-
like macrophages contribute to metabolic inflammation and insulin resistance, those …

Obesity is a major risk factor for type 2 diabetes and a trigger of chronic and systemic
inflammation. Recent evidence suggests that an increased burden of senescent cells (SCs) …

Identifying molecular circuits that control adipose tissue macrophage (ATM) function is
necessary to understand how ATMs contribute to tissue homeostasis and obesity-induced …

Insulin resistance (IR) during obesity is linked to adipose tissue macrophage (ATM)-driven
inflammation of adipose tissue. Whether anti-inflammatory glucocorticoids (GCs) at …

Oxidative stress (OxS) is the cause and the consequence of metabolic syndrome (MetS), the
incidence and economic burden of which is increasing each year. OxS triggers the …

Diabetic nephropathy (DN) is the principal cause of end-stage renal disease and results in
high morbidity and mortality in patients, causing a large socioeconomic burden. Multiple …

Obesity is associated with insulin resistance and low-grade inflammation. Insulin resistance
is a risk factor for cancer. A recent chapter in epigenetics is represented by microRNAs …

Cynanchum acutum L. is a climbing vine that belongs to the family Apocynaceae. Using
different chromatographic techniques, seven compounds were isolated from the methanolic …