The role of heat shock proteins in metastatic colorectal cancer: A review

H Javid, P Hashemian, S Yazdani… - Journal of Cellular …, 2022 - Wiley Online Library
Heat shock proteins (HSPs) are a large molecular chaperone family classified by their
molecular weights, including HSP27, HSP40, HSP60, HSP70, HSP90, and HSP110. HSPs …

Immunotherapy for colorectal cancer: Rational strategies and novel therapeutic progress

F Rastin, H Javid, MA Oryani, N Rezagholinejad… - International …, 2024 - Elsevier
There are increasing incidences and mortality rates for colorectal cancer in the world. It is
common for chemotherapy and radiation given to patients with colorectal cancer to cause …

The SP/NK1R system promotes the proliferation of breast cancer cells through NF-κB-mediated inflammatory responses

S Jafarinezhad, R Assaran Darban, H Javid… - Cell Biochemistry and …, 2023 - Springer
Background Numerous molecules have been introduced to participate in the formation of
breast cancer, the most common malignancy in women. Among them, neuropeptide …

The anti-tumoral role of Hesperidin and Aprepitant on prostate cancer cells through redox modifications

S Akbari, R Assaran Darban, H Javid… - Naunyn-Schmiedeberg's …, 2023 - Springer
Prostate cancer is the second prevalent cancer in men. While the anti-cancer effect of
Hesperidin and (Aprepitant) AP on prostate cancer cells is well documented, their combined …

[HTML][HTML] Evolving strategies and application of proteins and peptide therapeutics in cancer treatment

AG Mukherjee, UR Wanjari, AV Gopalakrishnan… - Biomedicine & …, 2023 - Elsevier
Several proteins and peptides have therapeutic potential and can be used for cancer
therapy. By binding to cell surface receptors and other indicators uniquely linked with or …

Aprepitant inhibits JNK and p38/MAPK to attenuate inflammation and suppresses inflammatory pain

Y Yang, W Zhou, X Xu, X Ge, F Wang… - Frontiers in …, 2022 - frontiersin.org
Substance P contributes to the pathogenesis of pain by acting on NK-1R, specialized
sensory neurons that detect noxious stimuli. Aprepitant, an antagonist of NK-1R, is widely …

The therapeutic potential of aprepitant in glioblastoma cancer cells through redox modification

S Rezaei, R Assaran Darban, H Javid… - BioMed Research …, 2022 - Wiley Online Library
Although there is no doubt regarding the involvement of oxidative stress in the development
of glioblastoma, many questions remained unanswered about signaling cascades that …

Substance P promotes the progression of bronchial asthma through activating the PI3K/AKT/NF-κB pathway mediated cellular inflammation and pyroptotic cell death …

M Li, X Zhong, WT Xu - Cell Cycle, 2022 - Taylor & Francis
ABSTRACT NOD-like receptor family pyrin domain containing three (NLRP3) inflammasome-
mediated pyroptotic cell death and inflammation contribute to the pathogenesis of bronchial …

Neurokinin-1 receptor (NK-1R) antagonists as a new strategy to overcome cancer resistance

M García-Aranda, T Téllez, L McKenna, M Redondo - Cancers, 2022 - mdpi.com
Simple Summary Improving the response, quality of life and survival of oncologic patients
through the design and application of the most appropriate treatment for each case is a great …

The repurposing of non-peptide neurokinin-1 receptor antagonists as antitumor drugs: An urgent challenge for aprepitant

R Coveñas, FD Rodríguez, P Robinson… - International journal of …, 2023 - mdpi.com
The substance P (SP)/neurokinin-1 receptor (NK-1R) system is involved in cancer
progression. NK-1R, activated by SP, promotes tumor cell proliferation and migration …