Cannabis use disorder (CUD) is an underappreciated risk of using cannabis that affects~
10% of the 193 million cannabis users worldwide. The individual and public health burdens …

We conducted a systematic review of meta-analyses and systematic reviews to evaluate the
impact of cannabis use on the onset and course of psychoses. Following a systematic …

Mendelian randomisation (MR) studies allow a better understanding of the causal effects of
modifiable exposures on health outcomes, but the published evidence is often hampered by …

Behaviors and disorders related to self-regulation, such as substance use, antisocial
behavior and attention-deficit/hyperactivity disorder, are collectively referred to as …

Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying
susceptibility genes could highlight the underlying pathophysiological mechanisms. We …

As recreational use of cannabis is being decriminalized in many places and medical use
widely sanctioned, there are growing concerns about increases in cannabis use disorder …

Background Variation in liability to cannabis use disorder has a strong genetic component
(estimated twin and family heritability about 50–70%) and is associated with negative …

Evidence supports the observational associations of gut microbiota with a variety of
psychiatric disorders, but the causal nature of such associations remains obscure. Aiming to …

Problematic alcohol use (PAU) is a leading cause of death and disability worldwide.
Although genome-wide association studies have identified PAU risk genes, the genetic …

Genetic correlation (rg) analysis is used to identify phenotypes that may have a shared
genetic basis. Traditionally, rg is studied globally, considering only the average of the …