Current dogma is that there exists a hematopoietic pluripotent stem cell, resident in the
marrow, which is quiescent, but with tremendous proliferative and differentiative potential …

Hematopoiesis has been considered hierarchical in nature, but recent data suggest that the
system is not hierarchical and is, in fact, quite functionally plastic. Existing data indicate that …

Hematopoietic stem cells (HSC) are multipotent cells that produce the various lineages of
blood and HSC transplantations (HSCT) are widely used to reconstitute damaged bone …

We have investigated the hematopoietic phenotype of mice with a hypomorphic mutation in
the Brca2/Fancd1 gene (Brca2 Δ27/Δ27 mutation). In contrast to observations made in other …

Marrow stem cell regulation represents a complex and flexible system. It has been assumed
that the system was intrinsically hierarchical in nature, but recent data has indicated that at …

The phenotype of marrow hematopoietic stem cells is determined by cell-cycle state and
microvesicle entry into the stem cells. The stem cell population is continually changing …

Phage display peptide libraries have enabled the discovery of peptides that selectively
target specific organs. Selection of organ‐specific peptides is mediated through binding of …

Many different subpopulations of subcellular extracellular vesicles (EVs) have been
described. EVs are released from all cell types and have been shown to regulate normal …

In many ways, the homing of hematopoietic stem cells to bone marrow and other tissues
defines these cells and their immediate and long-term fates Once homed, an inevitable …

We studied the genetic and engraftment phenotype of highly purified murine hematopoietic
stem cells (lineage negative, rhodamine-low, Hoechst-low) through cytokine-stimulated cell …