Traumatic brain injury: Ultrastructural features in neuronal ferroptosis, glial cell activation and polarization, and blood–brain barrier breakdown
D Qin, J Wang, A Le, TJ Wang, X Chen, J Wang - Cells, 2021 - mdpi.com
The secondary injury process after traumatic brain injury (TBI) results in motor dysfunction,
cognitive and emotional impairment, and poor outcomes. These injury cascades include …
cognitive and emotional impairment, and poor outcomes. These injury cascades include …
Perspectives on the mechanism of pyroptosis after intracerebral hemorrhage
D Song, CT Yeh, J Wang, F Guo - Frontiers in Immunology, 2022 - frontiersin.org
Intracerebral hemorrhage (ICH) is a highly harmful neurological disorder with high rates of
mortality, disability, and recurrence. However, effective therapies are not currently available …
mortality, disability, and recurrence. However, effective therapies are not currently available …
Diet‐induced high serum levels of trimethylamine‐N‐oxide enhance the cellular inflammatory response without exacerbating acute intracerebral hemorrhage injury in …
C Li, L Zhu, Y Dai, Z Zhang, L Huang… - Oxidative medicine …, 2022 - Wiley Online Library
Trimethylamine‐N‐oxide (TMAO), an intestinal flora metabolite of choline, may aggravate
atherosclerosis by inducing a chronic inflammatory response and thereby promoting the …
atherosclerosis by inducing a chronic inflammatory response and thereby promoting the …
An enriched environment improves long-term functional outcomes in mice after intracerebral hemorrhage by mechanisms that involve the Nrf2/BDNF/glutaminase …
P Jia, J Wang, X Ren, J He, S Wang… - Journal of Cerebral …, 2023 - journals.sagepub.com
Post-stroke depression exacerbates neurologic deficits and quality of life. Depression after
ischemic stroke is known to some extent. However, depression after intracerebral …
ischemic stroke is known to some extent. However, depression after intracerebral …
Profiling of blood-brain barrier disruption in mouse intracerebral hemorrhage models: collagenase injection vs. autologous arterial whole blood infusion
P Jia, J He, Z Li, J Wang, L Jia, R Hao, J Lai… - Frontiers in Cellular …, 2021 - frontiersin.org
Disruption of the blood-brain barrier (BBB) and the subsequent formation of brain edema is
the most severe consequence of intracerebral hemorrhage (ICH), leading to drastic …
the most severe consequence of intracerebral hemorrhage (ICH), leading to drastic …
Focused update on stroke neuroimmunology: current progress in preclinical and clinical research and recent mechanistic insight
J Boltze, MA Perez-Pinzon - Stroke, 2022 - Am Heart Assoc
Local and systemic inflammation contribute significantly to stroke risk factors as well as
determining stroke impact and outcome. Previously being considered as an immuno …
determining stroke impact and outcome. Previously being considered as an immuno …
GLP-1R agonist exendin-4 protects against hemorrhagic transformation induced by rtPA after ischemic stroke via the Wnt/β-catenin signaling pathway
C Liu, S Sun, J Xie, H Li, T Li, Q Wu, Y Zhang… - Molecular …, 2022 - Springer
Tissue plasminogen activator (tPA) is recommended by the FDA to dissolve intravascular
clots after acute ischemic stroke (AIS). However, it may contribute to hemorrhagic …
clots after acute ischemic stroke (AIS). However, it may contribute to hemorrhagic …
A clinically relevant model of focal embolic cerebral ischemia by thrombus and thrombolysis in rhesus monkeys
Over decades of research into the treatment of stroke, nearly all attempts to translate
experimental treatments from discovery in cells and rodents to use in humans have failed …
experimental treatments from discovery in cells and rodents to use in humans have failed …
Dapsone, more than an effective neuro and cytoprotective drug
A Diaz-Ruiz, J Nader-Kawachi… - Current …, 2022 - benthamdirect.com
Background: Dapsone (4, 4'-diamino-diphenyl sulfone) is a synthetic derivative of sulfones,
with the antimicrobial activity described since 1937. It is also a drug traditionally used in …
with the antimicrobial activity described since 1937. It is also a drug traditionally used in …
Phenotype shifting in astrocytes account for benefits of intra-arterial selective cooling infusion in hypertensive rats of ischemic stroke
L Wang, L Wu, Y Duan, S Xu, Y Yang, J Yin, Y Lang… - …, 2022 - Springer
The translational failure of neuroprotective therapies in stroke may be influenced by the
mismatch of existing comorbidities between animal models and patients. Previous studies …
mismatch of existing comorbidities between animal models and patients. Previous studies …