How the gut parasitome affects human health

G Ianiro, A Iorio, S Porcari, L Masucci… - Therapeutic …, 2022 - journals.sagepub.com
The human gut microbiome (GM) is a complex ecosystem that includes numerous
prokaryotic and eukaryotic inhabitants. The composition of GM can influence an array of host …

NF-κB Signaling Pathway in Rheumatoid Arthritis: Mechanisms and Therapeutic Potential

H Liao, J Zheng, J Lu, H Shen - Molecular Neurobiology, 2024 - Springer
Rheumatoid arthritis (RA) is an autoimmune chronic inflammatory disease that imposes a
heavy economic burden on patients and society. Bone and cartilage destruction is …

Giardia duodenalis and Its Secreted PPIB Trigger Inflammasome Activation and Pyroptosis in Macrophages through TLR4-Induced ROS Signaling and A20-Mediated …

L Liu, Y Yang, R Fang, W Zhu, J Wu, X Li, JV Patankar… - Cells, 2021 - mdpi.com
The extracellular protozoan parasite Giardia duodenalis is a well-known and important
causative agent of diarrhea on a global scale. Macrophage pyroptosis has been recognized …

Lipidome of extracellular vesicles from Giardia lamblia

CP Faria, B Ferreira, Á Lourenço, I Guerra, T Melo… - Plos one, 2023 - journals.plos.org
Extracellular vesicles (EVs)(exossomes, microvesicles and apoptotic bodies) have been
well acknowledged as mediators of intercellular communications in prokaryotes and …

Resveratrol can attenuate astrocyte activation to treat spinal cord injury by inhibiting inflammatory responses

R Fan, Y Zhang, BOA Botchway, X Liu - Molecular Neurobiology, 2021 - Springer
Several preclinical and clinical studies have attempted to elucidate the pathophysiological
mechanism associated with spinal cord injury. However, investigations have been unable to …

Pancreatic cancer cell-derived microRNA-155-5p-containing extracellular vesicles promote immune evasion by triggering EHF-dependent activation of Akt/NF-κB …

S Wang, Y Gao - International Immunopharmacology, 2021 - Elsevier
Pancreatic cancer (PC)-derived EVs have been extensively investigated due to their
promising potential as disease biomarkers for diagnosis, monitoring, and treatment …

Trophozoite fitness dictates the intestinal epithelial cell response to Giardia intestinalis infection

J Grüttner, JM van Rijn, P Geiser, A Florbrant… - PLoS …, 2023 - journals.plos.org
Giardia intestinalis is a non-invasive, protozoan parasite infecting the upper small intestine
of most mammals. Symptomatic infections cause the diarrhoeal disease giardiasis in …

Giardia duodenalis Induces Proinflammatory Cytokine Production in Mouse Macrophages via TLR9-Mediated p38 and ERK Signaling Pathways

X Pu, X Li, L Cao, K Yue, P Zhao, X Wang… - Frontiers in cell and …, 2021 - frontiersin.org
Giardia duodenalis, also known as Giardia lamblia or Giardia intestinalis, is an important
opportunistic, pathogenic, zoonotic, protozoan parasite that infects the small intestines of …

Echinococcus granulosus cyst fluid suppresses inflammatory responses by inhibiting TRAF6 signalling in macrophages

K Lin, D Zhou, M Li, J Meng, F He, X Yang, D Dong… - Parasitology, 2021 - cambridge.org
Echinococcus granulosus sensu lato has complex defence mechanisms that protect it from
the anti-parasitic immune response for long periods. Echinococcus granulosus cyst fluid …

The Anti-Apoptotic Role of COX-2 during In Vitro Infection of Human Intestinal Cell Line by Giardia duodenalis and the Potential Regulators

Y Yang, Y Zhao, L Liu, W Zhu, S Jia, X Li… - Infection and …, 2022 - Am Soc Microbiol
The protozoan parasite Giardia duodenalis inhabits the upper small intestine of mammals,
including humans, and causes a disease known as giardiasis, which can lead to diarrhea …