Reproductive function adjusts in response to environmental conditions in order to optimize
success. In humans, this plasticity includes age of pubertal onset, hormone levels and age at …

Pioneer transcription factors are proteins with a dual function. First, they regulate
transcription by binding to nucleosome-free DNA regulatory elements. Second, they bind to …

Promoters play a central role in controlling gene regulation; however, a small set of
promoters is used for most genetic construct design in the yeast Saccharomyces cerevisiae …

Sequence-specific protein-DNA interactions are at the heart of the response of the tumor-
suppressor p53 to numerous physiological and stress-related signals. Large variability has …

The advent of single-molecule force spectroscopy represents the introduction of forces,
torques, and displacements as controlled variables in biochemistry. These methods afford …

The structure of promoter chromatin determines the ability of transcription factors (TFs) to
bind to DNA and therefore has a profound effect on the expression levels of genes …

Chromatosomes play a fundamental role in chromatin regulation, but a detailed
understanding of their structure is lacking, partially due to their complex dynamics. Using …

Genome-wide studies have demonstrated regulatory roles for diverse non-coding elements,
but their precise and interrelated functions have often remained enigmatic. Addressing the …

Metal ions can perform multiple roles ranging from regulatory to structural and are crucial for
cell function. While some metal ions like Na+ are ubiquitously present at high …

CpG islands recruit MLL1 via the CXXC domain to modulate chromatin structure and
regulate gene expression. The amino acid motif of CXXC also plays a pivotal role in MLL1's …