Adverse side effects of 5α-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients

AM Traish, J Hassani, AT Guay… - The journal of sexual …, 2011 - academic.oup.com
ABSTRACT Introduction 5α-reductase inhibitors (5α-RIs), finasteride and dutasteride, have
been approved for treatment of lower urinary tract symptoms, due to benign prostatic …

Onset of effects of testosterone treatment and time span until maximum effects are achieved

F Saad, A Aversa, AM Isidori, L Zafalon… - European Journal of …, 2011 - academic.oup.com
Objective Testosterone has a spectrum of effects on the male organism. This review attempts
to determine, from published studies, the time-course of the effects induced by testosterone …

Long‐term testosterone treatment in elderly men with hypogonadism and erectile dysfunction reduces obesity parameters and improves metabolic syndrome and …

DJ Yassin, G Doros, PG Hammerer… - The journal of sexual …, 2014 - academic.oup.com
Introduction Late‐onset hypogonadism (LOH) is diagnosed when declining testosterone
concentrations in the aging male cause unwanted symptoms such as erectile dysfunction …

Testosterone replacement therapy with long‒acting testosterone undecanoate improves sexual function and quality‒of‒life parameters vs. placebo in a population of …

G Hackett, N Cole, M Bhartia, D Kennedy… - The journal of sexual …, 2013 - academic.oup.com
Introduction Sexual dysfunction, particularly erectile dysfunction (ED), is common in men
with type 2 diabetes, occurring in up to 75% of cases. The prevalence of hypogonadism is …

The response to testosterone undecanoate in men with type 2 diabetes is dependent on achieving threshold serum levels (the BLAST study)

G Hackett, N Cole, M Bhartia… - … journal of clinical …, 2014 - Wiley Online Library
Background The association between testosterone deficiency and insulin resistance in men
with type 2 diabetes is well established. Current Endocrine Society and European …

Challenges in testosterone measurement, data interpretation, and methodological appraisal of interventional trials

LW Trost, JP Mulhall - The journal of sexual medicine, 2016 - academic.oup.com
Introduction Male hypogonadism is a common condition, with an increasing body of
literature on diagnosis, implications, and management. Given the significant variability in …

Mechanisms of obesity and related pathologies: androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction

AM Traish, RJ Feeley, A Guay - The FEBS journal, 2009 - Wiley Online Library
Obesity is associated with a high prevalence of erectile dysfunction; however, the
pathophysiological link between obesity and erectile dysfunction remains poorly …

The role of penile color-duplex ultrasound for the evaluation of erectile dysfunction

A Aversa, LM Sarteschi - The journal of sexual medicine, 2007 - academic.oup.com
Introduction In the era of orally active agents, dynamic penile color-duplex ultrasound (D-
PCDU) is not considered a necessary first screening for all patients with erectile dysfunction …

Testosterone regulates RhoA/Rho-kinase signaling in two distinct animal models of chemical diabetes

L Vignozzi, A Morelli, S Filippi… - The journal of sexual …, 2007 - academic.oup.com
ABSTRACT Introduction The contractile RhoA/Rho-kinase (ROCK) signaling pathway is
upregulated in penile tissue in animal models of experimental diabetes and has been …

Effects of 8-year treatment of long-acting testosterone undecanoate on metabolic parameters, urinary symptoms, bone mineral density, and sexual function in men with …

S Permpongkosol, K Khupulsup… - The Journal of …, 2016 - academic.oup.com
Introduction The long-term effects of long-acting testosterone undecanoate (TU) and
androgen receptor CAG repeat lengths in Thai men with late-onset hypogonadism (LOH) …