Tumor DNA mismatch repair (MMR) deficiency testing is important to the identification of
Lynch syndrome and decision making regarding adjuvant chemotherapy in stage II …

The acidic tumour microenvironment is now recognized as a tumour phenotype that drives
cancer somatic evolution and disease progression, causing cancer cells to become more …

The development of hyperpolarized bioresponsive probes for magnetic resonance imaging
(MRI) applications is an emerging and rapidly growing topic in chemistry. A wide range of …

Dysregulation of pH in solid tumors is a hallmark of cancer. In recent years, the role of
altered pH heterogeneity in space, between benign and aggressive tissues, between …

In vivo monitoring of cerebral pH is of great significance because its disturbance is related to
some pathological processes such as neurodegenerative diseases, for example …

Hyperpolarization stands out as a technique capable of significantly enhancing the
sensitivity of nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) …

A robust and selective late-stage deuteration methodology was applied to 13C-enriched
amino and alpha hydroxy acids to increase spin–lattice relaxation constant T1 for …

pH is a tightly regulated physiological parameter that is often altered in diseased states like
cancer. The development of biosensors that can be used to non-invasively image pH with …

The embedding of radicals at different locations within core@ shell silica nanoparticles
contributes to enhanced polarization capability and can be self-polarized without adding …

In this work, a novel fluorescence “turn-on” probe CADB was designed and synthesized by
the condensation reaction of camphor-derived quinoxalin-1, 4-diamine (2) and 4-bromo-2 …