Myofibroblasts are a unique group of smooth-muscle-like fibroblasts that have a similar
appearance and function regardless of their tissue of residence. Through the secretion of …

Celiac disease (CD) is an intestinal disorder with multifactorial etiology. HLA and non-HLA
genes together with gluten and possibly additional environmental factors are involved in …

Our knowledge of celiac disease pathogenesis has recently made rapid progress. The
disorder is now considered the result of a complex interplay of intrinsic (genetic) and …

Intestinal subepithelial myofibroblasts (ISEMF) and the interstitial cells of Cajal are the two
types of myofibroblasts identified in the intestine. Intestinal myofibroblasts are activated and …

Citrobacter rodentium is a classically noninvasive pathogen of mice that is similar to
enteropathogenic Escherichia coli (EPEC) in man. Following oral infection of young mice …

The proglucagon-derived peptide glucagon-like peptide 2 (GLP-2), a product of a subset of
gut epithelial cells, is pursued clinically for its ability to stimulate gut epithelial growth and …

In a previous screening study, 16% of patients with psoriasis had IgA and/or IgG antibodies
to gliadin (AGA). The aim of the present study was to evaluate the effect of a gluten‐free diet …

Background & Aims: Villous atrophy and crypt proliferation are key epithelial features of
untreated celiac disease. We tried to define whether cytokines such as interleukin (IL)-15, IL …

Crohn's disease and ulcerative colitis are caused by excessive immune reactivity in the gut
wall. Analysis of the type of immune responses ongoing in diseased gut has revealed …

Oral and intestinal mucositis are among the most significant dose-limiting toxic effects of
intensive cancer treatment and are associated with adverse clinical and economic …