Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: integration of the glutamate/GABA-glutamine cycle

JV Andersen, A Schousboe, A Verkhratsky - Progress in neurobiology, 2022 - Elsevier
Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

Lipids and Alzheimer's disease

YC Kao, PC Ho, YK Tu, IM Jou, KJ Tsai - International journal of molecular …, 2020 - mdpi.com
Lipids, as the basic component of cell membranes, play an important role in human health
as well as brain function. The brain is highly enriched in lipids, and disruption of lipid …

Oxidative stress, synaptic dysfunction, and Alzheimer's disease

E Tönnies, E Trushina - Journal of Alzheimer's Disease, 2017 - content.iospress.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure. Most
AD cases are sporadic where age represents the greatest risk factor. Lack of understanding …

Involvement of astrocytes in Alzheimer's disease from a neuroinflammatory and oxidative stress perspective

RE González-Reyes, MO Nava-Mesa… - Frontiers in molecular …, 2017 - frontiersin.org
Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in
humans, but still no curative treatment has been developed. Although many explicative …

The clinical promise of biomarkers of synapse damage or loss in Alzheimer's disease

M Colom-Cadena, T Spires-Jones, H Zetterberg… - Alzheimer's research & …, 2020 - Springer
Background Synapse damage and loss are fundamental to the pathophysiology of
Alzheimer's disease (AD) and lead to reduced cognitive function. The goal of this review is to …

[HTML][HTML] Is Alzheimer's disease a type 3 diabetes? A critical appraisal

R Kandimalla, V Thirumala, PH Reddy - Biochimica et Biophysica Acta …, 2017 - Elsevier
Recently researchers proposed the term 'Type-3-Diabetes' for Alzheimer's disease (ad)
because of the shared molecular and cellular features among Type-1-Diabetes, Type-2 …

The neuroprotective effects of glucagon-like peptide 1 in Alzheimer's and Parkinson's disease: An in-depth review

N Reich, C Hölscher - Frontiers in neuroscience, 2022 - frontiersin.org
Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

Astrocytes: a central element in neurological diseases

M Pekny, M Pekna, A Messing, C Steinhäuser… - Acta …, 2016 - Springer
The neurone-centred view of the past disregarded or downplayed the role of astroglia as a
primary component in the pathogenesis of neurological diseases. As this concept is …

The role of reactive oxygen species in the pathogenesis of Alzheimer's disease, Parkinson's disease, and Huntington's disease: a mini review

S Manoharan, GJ Guillemin… - Oxidative medicine …, 2016 - Wiley Online Library
Neurodegenerative diseases affect not only the life quality of aging populations, but also
their life spans. All forms of neurodegenerative diseases have a massive impact on the …

[HTML][HTML] Butyrate, neuroepigenetics and the gut microbiome: Can a high fiber diet improve brain health?

MW Bourassa, I Alim, SJ Bultman, RR Ratan - Neuroscience letters, 2016 - Elsevier
As interest in the gut microbiome has grown in recent years, attention has turned to the
impact of our diet on our brain. The benefits of a high fiber diet in the colon have been well …