Currently, the development of anticancer drug resistance is significantly restricted the clinical
efficacy of the most commonly prescribed anticancer drug. Malignant disease is widely …

Human protein farnesyltransferase (FTase) catalyzes the addition of a C15-farnesyl lipid
group to the cysteine residue located in the COOH-terminal tetrapeptide motif of a variety of …

Benzodioxane has long been a versatile template widely employed to design molecules
endowed with diverse bioactivities. Its use spans the last decades of medicinal chemistry …

A SAR study was performed on 3-substituted 2, 6-difluorobenzamides, known inhibitors of
the essential bacterial cell division protein FtsZ, through a series of modifications first of 2, 6 …

FtsZ is a crucial prokaryotic protein involved in bacterial cell replication. It recently arose as a
promising target in the search for antimicrobial agents able to fight antimicrobial resistance …

Background: The American trypanosomiasis, Chagas disease, is a parasitic infection
typically spread by triatomine vectors affecting millions of people all over Latin America …

A new family of indolizine–chalcones was designed, synthesized and screened for the
inhibitory potential on human farnesyltransferase in vitro to identify potent antitumor agents …

Protein prenylation is a critical mediator in several diseases including cancer and acquired
immunodeficiency syndrome (AIDS). Therapeutic intervention has focused primarily on …

The selectivity of α4β2 nAChR agonists over the α3β4 nicotinic receptor subtype,
predominant in ganglia, primarily conditions their therapeutic range and it is still a complex …

In contrast to previously reported free-radical pathways to functionalize imidazo [1, 2-a]
pyridines at the C-5 centre, directing group approaches are rare. Herein, we demonstrate a …