Growth plate chondrocytes play a pivotal role in promoting longitudinal bone growth. The
current review represents a brief survey of the phenomena involved in this process at the …

Purpose To provide a comprehensive overview of the basic science and clinical evidence
behind cartilage regeneration techniques as they relate to surgical management of chondral …

ACHONDROPLASIA, the most common cause of chondrodysplasia in man (1 in 15,000 live
births), is a condition of unknown origin characterized by short-limbed dwarfism and …

Fibroblast growth factor receptor 3 (Fgfr3) is a tyrosine kinase receptor expressed in
developing bone, cochlea, brain and spinal cord. Achondroplasia, the most common genetic …

Abstract C3H10T1/2 cells are an established mesenchymal stem cell line which can
differentiate into muscle, fat and cartilage cells when treated with azacytidine. Bone …

Vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) induces
endothelial cell migration and proliferation in culture and is strongly angiogenic in vivo …

Recent experiments have established that Sox9 is required for chondrocyte differentiation.
Here, we show that fibroblast growth factors (FGFs) markedly enhance Sox9 expression in …

Fibroblast growth factor receptor 3 (FGFR3) is a key regulator of skeletal growth and
activating mutations in Fgfr3 cause achondroplasia, the most common genetic form of …

Several genetic forms of human dwarfism have been linked to activating mutations in FGF
receptor 3, indicating that FGF signaling has a critical role in chondrocyte maturation and …

Chondrocytes are the exclusive cells residing in cartilage and maintain the functionality of
cartilage tissue. Series of biocomponents such as different growth factors, cytokines, and …