Non-alcoholic fatty liver disease: metabolic, genetic, epigenetic and environmental risk factors

O Juanola, S Martínez-López, R Francés… - International journal of …, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of chronic liver
disease in the Western world, probably due to the growing prevalence of obesity, metabolic …

Leveraging human genetics to identify potential new treatments for fatty liver disease

S Romeo, A Sanyal, L Valenti - Cell metabolism, 2020 - cell.com
Fatty liver disease (FLD), including its more severe pathologies, namely steatohepatitis,
hepatocarcinoma, and cirrhosis, is the most common cause of chronic liver disease …

Split-TurboID enables contact-dependent proximity labeling in cells

KF Cho, TC Branon, S Rajeev… - Proceedings of the …, 2020 - National Acad Sciences
Proximity labeling catalyzed by promiscuous enzymes, such as TurboID, have enabled the
proteomic analysis of subcellular regions difficult or impossible to access by conventional …

the emerging role of genetics in precision medicine for patients with non‐alcoholic steatohepatitis

B Carlsson, D Lindén, G Brolén… - Alimentary …, 2020 - Wiley Online Library
Background Non‐alcoholic steatohepatitis (NASH) is a severe form of non‐alcoholic fatty
liver disease (NAFLD) characterised by liver fat accumulation, inflammation and progressive …

MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis

VV Phadnis, J Snider, V Varadharajan… - Cell reports, 2023 - cell.com
Ferroptosis is a form of regulated cell death with roles in degenerative diseases and cancer.
Excessive iron-catalyzed peroxidation of membrane phospholipids, especially those …

Alcohol effects on hepatic lipid metabolism

S Jeon, R Carr - Journal of lipid research, 2020 - ASBMB
Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with
significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and …

A metabolic associated fatty liver disease risk variant in MBOAT7 regulates toll like receptor induced outcomes

J Alharthi, A Bayoumi, K Thabet, Z Pan… - Nature …, 2022 - nature.com
The breakdown of toll-like receptor (TLR) tolerance results in tissue damage, and
hyperactivation of the TLRs and subsequent inflammatory consequences have been …

Therapeutic opportunities for the treatment of NASH with genetically validated targets

D Lindén, S Romeo - Journal of Hepatology, 2023 - Elsevier
The identification of genetic variants associated with fatty liver disease (FLD) from genome-
wide association studies started in 2008 when single nucleotide polymorphisms in PNPLA3 …

NAFLD and atherosclerosis: two sides of the same dysmetabolic coin?

D Stols-Gonçalves, GK Hovingh, M Nieuwdorp… - Trends in Endocrinology …, 2019 - cell.com
The prevalence of non-alcoholic fatty liver disease (NAFLD) is strongly increasing and may
put patients at increased risk for atherosclerotic cardiovascular disease (asCVD). Both …

Genetics of MASLD: The State of Art Update.

S Sookoian, Y Rotman, L Valenti - Clinical Gastroenterology and …, 2024 - Elsevier
Recent advances in the genetics of metabolic dysfunction-associated steatotic liver disease
(MASLD) are gradually revealing the mechanisms underlying the heterogeneity of the …