[HTML][HTML] Function and regulation of the PEA3 subfamily of ETS transcription factors in cancer
T Qi, Q Qu, G Li, J Wang, H Zhu, Z Yang… - American journal of …, 2020 - ncbi.nlm.nih.gov
The PEA3 subfamily is a subgroup of the E26 transformation-specific (ETS) family. Its
members, ETV1, ETV4, and ETV5, have been found to be overexpressed in multiple …
members, ETV1, ETV4, and ETV5, have been found to be overexpressed in multiple …
Regulation and function of capicua in mammals
Y Lee - Experimental & molecular medicine, 2020 - nature.com
Capicua (CIC) is an evolutionarily conserved transcription factor. CIC contains a high-
mobility group (HMG) box that recognizes specific DNA sequences to regulate the …
mobility group (HMG) box that recognizes specific DNA sequences to regulate the …
The complete cell atlas of an aging multicellular organism
Here we describe a single-cell atlas of aging for the nematode Caenorhabditis elegans. This
unique resource describes the expression across adulthood of over 20,000 genes among …
unique resource describes the expression across adulthood of over 20,000 genes among …
Molecular and therapeutic advancements in Capicua (CIC)-rearranged sarcoma
RKM Ponce, C Luck, RA Okimoto - Frontiers in Cell and …, 2024 - frontiersin.org
Capicua (CIC)-rearranged sarcomas are an aggressive subset of undifferentiated round cell
sarcomas. CIC:: DUX4, the proto-typical CIC fusion oncoprotein is associated with rapid …
sarcomas. CIC:: DUX4, the proto-typical CIC fusion oncoprotein is associated with rapid …
E26 transformation-specific variant 4 as a tumor promotor in human cancers through specific molecular mechanisms
W Jiang, Y Xu, X Chen, S Pan, X Zhu - Molecular Therapy-Oncolytics, 2021 - cell.com
E26 transformation-specific (ETS) variant 4 (ETV4) is an important transcription factor that
belongs to the ETS transcription factor family and is essential for much cellular physiology …
belongs to the ETS transcription factor family and is essential for much cellular physiology …
The capicua-ataxin-1-like complex regulates Notch-driven marginal zone B cell development and sepsis progression
JS Park, M Kang, HB Kim, H Hong, J Lee… - Nature …, 2024 - nature.com
Follicular B (FOB) and marginal zone B (MZB) cells are pivotal in humoral immune
responses against pathogenic infections. MZB cells can exacerbate endotoxic shock via …
responses against pathogenic infections. MZB cells can exacerbate endotoxic shock via …
Capicua in human cancer
JW Kim, RK Ponce, RA Okimoto - Trends in cancer, 2021 - cell.com
Capicua (CIC) is a highly conserved transcriptional repressor that is differentially regulated
through mitogen-activated protein kinase (MAPK) signaling or genetic alteration across …
through mitogen-activated protein kinase (MAPK) signaling or genetic alteration across …
Capicua restricts cancer stem cell-like properties in breast cancer cells
Cancer stem cells (CSCs) play a central role in cancer initiation, progression, therapeutic
resistance, and recurrence in patients. Here we present Capicua (CIC), a developmental …
resistance, and recurrence in patients. Here we present Capicua (CIC), a developmental …
[HTML][HTML] Postnatal regulation of B-1a cell development and survival by the CIC-PER2-BHLHE41 axis
H Hong, J Lee, GY Park, S Kim, J Park, JS Park… - Cell Reports, 2022 - cell.com
B-1 cell development mainly occurs via fetal and neonatal hematopoiesis and is suppressed
in adult bone marrow hematopoiesis. However, little is known about the factors inhibiting B-1 …
in adult bone marrow hematopoiesis. However, little is known about the factors inhibiting B-1 …
ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth
Activation of receptor tyrosine kinase signaling inactivates capicua (CIC), a transcriptional
repressor that functions as a tumor suppressor, via degradation and/or cytoplasmic …
repressor that functions as a tumor suppressor, via degradation and/or cytoplasmic …