RNAs are central to fundamental biological processes in all known organisms. The set of
possible intramolecular interactions of RNA nucleotides defines the range of alternative …

Highlights•Conformational penalties to form alternative conformational states of nucleic
acids greatly contribute to nucleic acid-protein recognition.•Methods to determine nucleic …

Structured RNAs and RNA/protein complexes perform critical cellular functions. They often
contain structurally conserved tertiary contact “motifs,” whose occurrence simplifies the RNA …

RNA can fold into structures that mediate diverse cellular functions. Understanding how
RNA primary sequence directs the formation of functional structures requires methods that …

MicroRNAs-direct Argonaute proteins to repress complementary target mRNAs via mRNA
degradation or translational inhibition. While mammalian miRNA targeting has been well …

Background Pseudomonas aeruginosa (PA) is a ubiquitous, Gram-negative, bacteria that
can attribute its survivability to numerous sensing and signaling pathways; conferring fitness …

In duplex DNA, AT and GC form Watson-Crick base pairs, and Hoogsteen pairing only
dominates upon protein binding or DNA damage. Using NMR, we show that an AT …

RNA-binding proteins (RBPs) are essential regulators of gene expression at post-
transcriptional level, yet obtaining quantitative insights into RBP-RNA interactions in vivo …