The introduction of fluorine atoms into molecules and materials across many fields of
academic and industrial research is now commonplace, owing to their unique properties. A …

Piperidines and fluorine substituents are both independently indispensable components in
pharmaceuticals, agrochemicals and materials. Logically, the incorporation of fluorine atoms …

Fluorinated piperidines are desirable motifs for pharmaceutical and agrochemical research.
Nevertheless, general synthetic access remains out of reach. Herein, we describe a simple …

Abstract (4S)‐and (4R)‐configured aminoproline (Amp) residues were used as pH‐
responsive probes to tune the thermal stability of collagen triple helices in acidic and basic …

Gaining an understanding of the conformational behavior of fluorinated compounds would
allow for expansion of the current molecular design toolbox. In order to facilitate drug …

We present a comprehensive study on the conformational behavior of diversely substituted 4‐
fluorotetrahydrothiopyran derivatives. Through quantum chemical simulations including DFT …

Selective fluorination of the pyrrolidine ring in proline motifs has been found to induce
significant conformational changes that impact the structure and biological roles of modified …

The structure of bioactive compounds inside their biological target is mainly dictated by the
intermolecular interactions present in the binding side, whereas intramolecular interactions …

The gauche effect in fluorinated alkylammonium salts is well known and attributed either to
an intramolecular hydrogen bond or to an electrostatic attraction between the positively …

The fluorine Perlin-like effect is an NMR phenomenon characterized by| 1JC–Fax|<| 1JC–
Feq| in fluorinated six-membered rings and can be useful to determine the stereochemistry …