MicroRNAs (miRNAs) participate in most aspects of cellular differentiation and homeostasis,
and consequently have roles in many pathologies, including cancer. These small non …

The high mobility group protein 2 (HMGA2) regulates gene expression by binding to AT-rich
regions of DNA. Akin to other DNA architectural proteins, HMGA2 is highly expressed in …

Glioblastoma multiforme (GBM) is a lethal, therapy-resistant brain cancer consisting of
numerous tumor cell subpopulations, including stem-like glioma-initiating cells (GICs), which …

The protumor roles of alternatively activated (M2) tumor-associated macrophages (TAMs)
have been well established, and macrophage reprogramming is an important therapeutic …

Micro-ribonucleic acids (miRNAs) are important class of short regulatory RNA molecules
involved in regulation of several essential biological processes. In addition to Dicer and …

Recently miR-182 has been reported to be over-expressed in prostate cancer (PC) tissues,
however detailed functional analysis of miR-182-5p has not been carried out. The purpose …

Metastasis is a complex, multistep process involved in the progression of cancer from a
localized primary tissue to distant sites, often characteristic of the more aggressive forms of …

The transforming growth factor β (TGFβ) pathway plays critical roles during cancer cell
epithelial-mesenchymal transition (EMT) and metastasis. SMAD7 is both a transcriptional …

Objective MicroRNAs (miRNAs) are well-known regulators of disease pathogenesis and
have great potential as biomarkers and therapeutic targets. We aimed at profiling miRNAs in …

Ovarian cancer is one of the top gynecological malignancies that cause deaths among
females in the United States. At the molecular level, significant progress has been made in …