As is known to all, glioma, a global difficult problem, has a high malignant degree, high
recurrence rate and poor prognosis. We analyzed and summarized signal pathway of the …

Although recent advances in cancer treatment significantly improved the prognosis of
patients, drug resistance remains a major challenge. Targeting programmed cell death is a …

Mutations in the Krebs cycle enzyme IDH1 (isocitrate dehydrogenase (NADP (+)) 1) are
associated with better prognosis in gliomas. Though IDH1 mutant (IDH1R132H) tumors are …

Glioblastoma (GBM) is the most malignant and aggressive primary brain tumor and is highly
resistant to current therapeutic strategies. Previous studies have demonstrated that reactive …

Increasing evidence suggests the oncogenic role of missense mutation (AKT1-E17K) of
AKT1 gene in meningiomas. Upon investigating the connection between the pro …

Accumulated alterations in metabolic control provide energy and anabolic demands for
enhanced cancer cell proliferation. Exemplified by the Warburg effect, changes in glucose …

Intrahepatic cholangiocarcinoma (iCCA), the second most common primary liver cancer, is a
highly lethal epithelial cell malignancy exhibiting features of cholangiocyte differentiation …

Gliomas harbouring mutations in IDH1 (isocitrate dehydrogenase 1) are characterized by
greater sensitivity to chemotherapeutics. These mutants also exhibit diminished levels of …

Non-alcoholic fatty liver disease (NAFLD) is a major health burden in the Western world, as
the Western diet (WD) appears to be the driving force of this disease. However, the …

First Person is a series of interviews with the first authors of a selection of papers published
in Journal of Cell Science, helping early-career researchers promote themselves alongside …