Risk factors for Alzheimer's disease
RA Armstrong - Folia neuropathologica, 2019 - termedia.pl
Early reviews identified over 20 risk factors associated with Alzheimer's disease (AD)
including age, familial inheritance, exposure to aluminium, traumatic brain injury (TBI), and …
including age, familial inheritance, exposure to aluminium, traumatic brain injury (TBI), and …
Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease
RW Mahley, KH Weisgraber… - Proceedings of the …, 2006 - National Acad Sciences
The premise of this review is that apolipoprotein (apo) E4 is much more than a contributing
factor to neurodegeneration. ApoE has critical functions in redistributing lipids among CNS …
factor to neurodegeneration. ApoE has critical functions in redistributing lipids among CNS …
Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease
See Sarazin et al.(doi: 10.1093/brain/aww041) for a scientific commentary on this article.
The advent of the positron emission tomography tracer 18 F-AV1451 provides the unique …
The advent of the positron emission tomography tracer 18 F-AV1451 provides the unique …
Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus
Q Xu, A Bernardo, D Walker, T Kanegawa… - Journal of …, 2006 - Soc Neuroscience
To study the profile and regulation of apolipoprotein E (apoE) expression in the CNS, we
generated mice in which apoE expression can be detected in vivo with unprecedented …
generated mice in which apoE expression can be detected in vivo with unprecedented …
What causes Alzheimer's disease?
RA Armstrong - Folia neuropathologica, 2013 - termedia.pl
Since the earliest descriptions of Alzheimer's disease (AD), many theories have been
advanced as to its cause. These include:(1) exacerbation of aging,(2) degeneration of …
advanced as to its cause. These include:(1) exacerbation of aging,(2) degeneration of …
Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice
WJ Brecht, FM Harris, S Chang, I Tesseur… - Journal of …, 2004 - Soc Neuroscience
Apolipoprotein E (apoE) is found in amyloid plaques and neurofibrillary tangles (NFTs) in
Alzheimer's disease (AD) brains, but its role in their pathogenesis is unclear. Previously, we …
Alzheimer's disease (AD) brains, but its role in their pathogenesis is unclear. Previously, we …
Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice
FM Harris, WJ Brecht, Q Xu, I Tesseur… - Proceedings of the …, 2003 - National Acad Sciences
Apolipoprotein (apo) E4 increases the risk and accelerates the onset of Alzheimer's disease
(AD). However, the underlying mechanisms remain to be determined. We previously found …
(AD). However, the underlying mechanisms remain to be determined. We previously found …
Lipid-and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity
S Chang, T Ma, RD Miranda… - Proceedings of the …, 2005 - National Acad Sciences
Apolipoprotein (apo) E4, a 299-aa protein and a major risk factor for Alzheimer's disease,
can be cleaved to generate C-terminal-truncated fragments that cause neurotoxicity in vitro …
can be cleaved to generate C-terminal-truncated fragments that cause neurotoxicity in vitro …
Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease
Abstract Apolipoprotein E4 (apoE4) is a major risk factor for Alzheimer's disease (AD).
Several hypotheses have been proposed to explain the association of the APOE ε4 allele …
Several hypotheses have been proposed to explain the association of the APOE ε4 allele …
Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE …
Alzheimer's disease (AD) is the most commonly diagnosed form of dementia in the elderly.
Predominantly this disease is sporadic in nature with only a small percentage of patients …
Predominantly this disease is sporadic in nature with only a small percentage of patients …