The role of RHIM in necroptosis
T Riebeling, U Kunzendorf… - Biochemical Society …, 2022 - portlandpress.com
The RIP homotypic interaction motif (RHIM) is a conserved protein domain that is
approximately 18–22 amino acids in length. In humans, four proteins carrying RHIM …
approximately 18–22 amino acids in length. In humans, four proteins carrying RHIM …
Higher-order assemblies in innate immune and inflammatory signaling: A general principle in cell biology
Higher-order supramolecular complexes–dubbed signalosomes carry out key signaling and
effector functions in innate immunity and inflammation. In this review, we present several …
effector functions in innate immunity and inflammation. In this review, we present several …
Z-RNA and the flipside of the SARS Nsp13 Helicase: is there a role for flipons in coronavirus-induced pathology?
A Herbert, M Poptsova - Frontiers in Immunology, 2022 - frontiersin.org
We present evidence suggesting that the severe acute respiratory syndrome (SARS)
coronavirus non-structural protein 13 (Nsp13) modulates the Z-RNA dependent regulated …
coronavirus non-structural protein 13 (Nsp13) modulates the Z-RNA dependent regulated …
Z‐Nucleic Acid Sensing and Activation of ZBP1 in Cellular Physiology and Disease Pathogenesis
S Mishra, AA Dey, S Kesavardhana - Immunological Reviews, 2025 - Wiley Online Library
ABSTRACT Z‐nucleic acid binding protein 1 (ZBP1) is an innate immune sensor
recognizing nucleic acids in Z‐conformation. Upon Z‐nucleic acid sensing, ZBP1 triggers …
recognizing nucleic acids in Z‐conformation. Upon Z‐nucleic acid sensing, ZBP1 triggers …
[HTML][HTML] Bat RNA viruses employ viral RHIMs orchestrating species-specific cell death programs linked to Z-RNA sensing and ZBP1-RIPK3 signaling
S Mishra, D Jain, AA Dey, S Nagaraja, M Srivastava… - iScience, 2024 - cell.com
RHIM is a protein motif facilitating the assembly of large signaling complexes triggering
regulated cell death. A few DNA viruses employ viral RHIMs mimicking host RHIMs and …
regulated cell death. A few DNA viruses employ viral RHIMs mimicking host RHIMs and …
TAT–RHIM: a more complex issue than expected
B Kolbrink, T Riebeling, NK Teiwes… - Biochemical …, 2022 - portlandpress.com
Murine cytomegalovirus protein M45 contains a RIP homotypic interaction motif (RHIM) that
is sufficient to confer protection of infected cells against necroptotic cell death …
is sufficient to confer protection of infected cells against necroptotic cell death …
The homo-and hetero-oligomeric foldomes of functional and pathological amyloids
Many aspects relating amyloid protein aggregation to function and disease are still
unknown. Amyloids are assumed to be made of one type of protein, but our recent …
unknown. Amyloids are assumed to be made of one type of protein, but our recent …