The art of finding the right drug target: emerging methods and strategies
Drug targets are specific molecules in biological tissues and body fluids that interact with
drugs. Drug target discovery is a key component of drug discovery and is essential for the …
drugs. Drug target discovery is a key component of drug discovery and is essential for the …
Disrupting pathologic phase transitions in neurodegeneration
BT Hurtle, L Xie, CJ Donnelly - The Journal of clinical …, 2023 - Am Soc Clin Investig
Solid-like protein deposits found in aged and diseased human brains have revealed a
relationship between insoluble protein accumulations and the resulting deficits in neurologic …
relationship between insoluble protein accumulations and the resulting deficits in neurologic …
Pathogenic tau induces an adaptive elevation in mRNA translation rate at early stages of disease
Alterations in the rate and accuracy of messenger RNA (mRNA) translation are associated
with aging and several neurodegenerative disorders, including Alzheimer's disease and …
with aging and several neurodegenerative disorders, including Alzheimer's disease and …
A genome‐wide association meta‐analysis of all‐cause and vascular dementia
Mega Vascular Cognitive Impairment and … - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Dementia is a multifactorial disease with Alzheimer's disease (AD) and
vascular dementia (VaD) pathologies making the largest contributions. Yet, most genome …
vascular dementia (VaD) pathologies making the largest contributions. Yet, most genome …
The Role of Retrotransposons and Endogenous Retroviruses in Age-Dependent Neurodegenerative Disorders
Over 40% of the human genome is composed of retrotransposons, DNA species that hold
the potential to replicate via an RNA intermediate and are evolutionarily related to …
the potential to replicate via an RNA intermediate and are evolutionarily related to …
[HTML][HTML] Tau-induced elevation of the activity-regulated cytoskeleton associated protein Arc1 causally mediates neurodegeneration in the adult Drosophila brain
Alzheimer's disease and other tauopathies are neurodegenerative disorders pathologically
defined by aggregated forms of tau protein in the brain. While synaptic degradation is a well …
defined by aggregated forms of tau protein in the brain. While synaptic degradation is a well …
Selective neuronal vulnerability to deficits in RNA processing
Emerging evidence indicates that errors in RNA processing can causally drive
neurodegeneration. Given that RNA produced from expressed genes of all cell types …
neurodegeneration. Given that RNA produced from expressed genes of all cell types …
Enhancing proteasome activity by NMDAR antagonists explains their therapeutic effect in neurodegenerative and mental diseases
NMDAR antagonists, such as memantine and ketamine, have shown efficacy in treating
neurodegenerative diseases and major depression. The mechanism by which these drugs …
neurodegenerative diseases and major depression. The mechanism by which these drugs …
[HTML][HTML] Multifaceted Role of Specialized Neuropeptide-Intensive Neurons on the Selective Vulnerability to Alzheimer's Disease in the Human Brain
M Li, N Flack, PA Larsen - Biomolecules, 2024 - mdpi.com
Regarding Alzheimer's disease (AD), specific neuronal populations and brain regions
exhibit selective vulnerability. Understanding the basis of this selective neuronal and …
exhibit selective vulnerability. Understanding the basis of this selective neuronal and …
[HTML][HTML] Brain Plasticity and Cell Competition: Immediate Early Genes Are the Focus
PP Tregub, YK Komleva, MV Kukla, AS Averchuk… - Cells, 2025 - mdpi.com
Brain plasticity is at the basis of many cognitive functions, including learning and memory. It
includes several mechanisms of synaptic and extrasynaptic changes, neurogenesis, and the …
includes several mechanisms of synaptic and extrasynaptic changes, neurogenesis, and the …