The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

Eukaryotic DNA-binding proteins operate in the context of chromatin, where nucleosomes
are the elementary building blocks. Nucleosomal DNA is wrapped around a histone core …

Chromatin compacts genomic DNA in eukaryotes. The primary chromatin unit is the
nucleosome core particle, composed of four pairs of the core histones, H2A, H2B, H3, and …

Molecular motors are diverse enzymes that transduce chemical energy into mechanical
work and, in doing so, perform critical cellular functions such as DNA replication and …

During replication, expression, and repair of the eukaryotic genome, cellular machinery must
access the DNA wrapped around histone proteins forming nucleosomes. These octameric …

Reproductive function adjusts in response to environmental conditions in order to optimize
success. In humans, this plasticity includes age of pubertal onset, hormone levels and age at …

DNA molecules with a total length of two meters contain the genetic information in every cell
in our body. To control access to the genes, to organize its spatial structure in the nucleus …

Transcription factors (TF) require access to target sites within nucleosomes to initiate
transcription. The target site position within the nucleosome significantly influences TF …

Eukaryotic genome and methylome encode DNA fragments' propensity to form nucleosome
particles. Although the mechanical properties of DNA possibly orchestrate such encoding …

Genomes are self-organized and self-maintained as long, complex macromolecules of
chromatin. The inherent heterogeneity, stochasticity, phase separation, and chromatin …