Towards systems tissue engineering: Elucidating the dynamics, spatial coordination, and individual cells driving emergent behaviors

MS Hall, JT Decker, LD Shea - Biomaterials, 2020 - Elsevier
Biomaterial systems have enabled the in vitro production of complex, emergent tissue
behaviors that were not possible with conventional two-dimensional culture systems …

[HTML][HTML] Adrenergic blockade promotes maintenance of dormancy in prostate cancer through upregulation of GAS6

AM Decker, JT Decker, Y Jung, FC Cackowski… - Translational …, 2020 - Elsevier
Men diagnosed with localized prostate cancer can develop metastases many years after
initial treatment, resulting in a poor prognosis. The purpose of this study was to investigate …

Dynamic Transcriptional Programs During Single NK Cell Killing: Connecting Form to Function in Cellular Immunotherapy

JT Decker, MS Hall, D Nanua, SM Orbach… - Cellular and Molecular …, 2024 - Springer
Introduction Natural killer (NK) cell-based therapies are a promising new method for treating
indolent cancer, however engineering new therapies is complex and progress towards …

Cyclin E overexpression confers resistance to trastuzumab through noncanonical phosphorylation of SMAD3 in HER2+ breast cancer

JT Decker, P Kandagatla, L Wan… - Cancer biology & …, 2020 - Taylor & Francis
The efficacy of trastuzumab, a treatment for HER2+ breast cancer, can be limited by the
development of resistance. Cyclin E (CCNE) overexpression has been implicated in …