The new WHO classification of adrenal cortical proliferations reflects translational advances
in the fields of endocrine pathology, oncology and molecular biology. By adopting a …

Chronic exposure to excess glucorticoids results in diverse manifestations of Cushing's
syndrome, including debilitating morbidities and increased mortality. Genetic and molecular …

The cAMP-dependent protein kinase (PKA) system represents a primary cell-signaling
pathway throughout systems and across species. PKA facilitates the actions of hormones …

Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that have the unique function of
terminating cyclic nucleotide signaling by catalyzing the hydrolysis of cAMP and GMP. They …

Both direct and indirect evidence demonstrate a central role for the cAMP-dependent protein
kinase (PKA) signaling pathway in the regulation of energy balance and metabolism across …

Background The heterogeneity in symptomatology and phenotypic profile attributable to
COVID-19 is widely unknown. The objective of this manuscript is to conduct a trans-ancestry …

PRKAR1A encodes the regulatory subunit type 1‐alpha (RIα) of the cyclic adenosine
monophosphate (cAMP)‐dependent protein kinase (PKA). Inactivating PRKAR1A mutations …

Approximately one-tenth of the general population exhibit adrenal cortical nodules, and the
incidence has increased. Afflicted patients display a multifaceted symptomatology …

Phosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides,
including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate …

Endocrine neoplasia syndromes feature a wide spectrum of benign and malignant tumors of
endocrine and non-endocrine organs associated with other clinical manifestations. This …