The suite of currently used drugs can be divided into two categories–traditional 'small
molecule'drugs with typical molecular weights of< 500 Da but with oral bioavailability, and …

This Review explores the class of plant-derived macrocyclic peptides called cyclotides. We
include an account of their discovery, characterization, and distribution in the plant kingdom …

In the last century, small-molecule natural products were the main inspiration for most drug
discovery programs based either on high-throughput screening (HTS) or rational design …

Inherent susceptibility of peptides to enzymatic degradation in the gastrointestinal tract is a
key bottleneck in oral peptide drug development. Here, we present a systematic analysis of …

Bioactive peptides have potential as drug leads, but turning them into drugs is a challenge
because of their typically poor metabolic stability. Molecular grafting is one approach to …

This article highlights new members, novel mechanisms of action, new functions, and
interesting applications of antimicrobial peptides reported in 2014. As of December 2014 …

The overexpression of Hdm2 and HdmX is a common mechanism used by many tumor cells
to inactive the p53 tumor suppressor pathway promoting cell survival. Targeting Hdm2 and …

Chronic pain is a universal health issue associated with numerous medical conditions, for
example after severe burns or following major surgery.[1] Compelling evidence suggests …

The structural complexity of many natural products sets them apart from common synthetic
drugs, allowing them to access a biological target space that lies beyond the enzyme active …

Objectives To determine the antibacterial activity of small cyclic plant proteins, ie cyclotides,
and the importance of the surface exposed charged residues for activity. Methods Prototypic …