Macrophages are a heterogeneous population of immune cells playing several and diverse
functions in homeostatic and immune responses. The broad spectrum of macrophage …

Metabolites produced by the host and microbiota play a crucial role in how human bodies
develop and remain healthy. Most of these metabolites are produced by microbiota and …

Summary Using untargeted metabolomics (n= 1,162 subjects), the plasma metabolite (m/z=
265.1188) phenylacetylglutamine (PAGln) was discovered and then shown in an …

Background Gut microbiota composition and function are symbiotically linked with host
health and altered in metabolic, inflammatory and neurodegenerative disorders. Three …

Detailed metabolic profiling in large-scale epidemiologic studies has uncovered novel
biomarkers for cardiometabolic diseases and clarified the molecular associations of …

Metabolomics deals with the whole ensemble of metabolites (the metabolome). As one of
the‐omic sciences, it relates to biology, physiology, pathology and medicine; but metabolites …

Trace amines are endogenous compounds classically regarded as comprising β-
phenylethyalmine, p-tyramine, tryptamine, p-octopamine, and some of their metabolites …

Mass spectrometry-and nuclear magnetic resonance-based metabolomic studies comparing
diseased versus healthy individuals have shown that microbial metabolites are often the …

Background Many metabolites serve as important signalling molecules to adjust cellular
activities and functions based on nutrient availability. Links between acetyl-CoA metabolism …

Macrophages represent the first line of defence in innate immune responses and
additionally serve important functions for the regulation of host inflammation and tissue …