Applications of single-cell sequencing in cancer research: progress and perspectives

Y Lei, R Tang, J Xu, W Wang, B Zhang, J Liu… - Journal of hematology & …, 2021 - Springer
Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …

Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine

B Niemann, S Haufs-Brusberg, L Puetz, M Feickert… - Nature, 2022 - nature.com
Brown adipose tissue (BAT) dissipates energy, and promotes cardiometabolic health. Loss
of BAT during obesity and ageing is a principal hurdle for BAT-centred obesity therapies, but …

A cell-type-specific atlas of the inner ear transcriptional response to acoustic trauma

B Milon, ED Shulman, KS So, CR Cederroth, EL Lipford… - Cell reports, 2021 - cell.com
Noise-induced hearing loss (NIHL) results from a complex interplay of damage to the
sensory cells of the inner ear, dysfunction of its lateral wall, axonal retraction of type 1C …

Marine microeukaryote metatranscriptomics: sample processing and bioinformatic workflow recommendations for ecological applications

NR Cohen, H Alexander, AI Krinos, SK Hu… - Frontiers in Marine …, 2022 - frontiersin.org
Microeukaryotes (protists) serve fundamental roles in the marine environment as
contributors to biogeochemical nutrient cycling and ecosystem function. Their activities can …

Unveiling adipose populations linked to metabolic health in obesity

I Reinisch, A Ghosh, F Noé, W Sun, H Dong, P Leary… - Cell Metabolism, 2024 - cell.com
Precision medicine is still not considered as a standard of care in obesity treatment, despite
a large heterogeneity in the metabolic phenotype of individuals with obesity. One of the …

Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape

I Reinisch, H Michenthaler, A Sulaj… - Nature …, 2024 - nature.com
In obesity, sustained adipose tissue (AT) inflammation constitutes a cellular memory that
limits the effectiveness of weight loss interventions. Yet, the impact of fasting regimens on …

The effects of herbarium specimen characteristics on short-read NGS sequencing success in nearly 8000 specimens: old, degraded samples have lower DNA yields …

HR Kates, JR Doby, CM Siniscalchi… - Frontiers in plant …, 2021 - frontiersin.org
Phylogenetic datasets are now commonly generated using short-read sequencing
technologies unhampered by degraded DNA, such as that often extracted from herbarium …

Next-generation sequencing (NGS) platforms: an exciting era of genome sequence analysis

B Meera Krishna, MA Khan, ST Khan - Microbial Genomics in Sustainable …, 2019 - Springer
DNA referred to as blueprint of life codes for the diversity and function of all the living
organisms. Determining DNA sequences of the living organisms not only gives an overview …

[HTML][HTML] Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue

A Gonzalez-Franquesa, P Gama-Perez, M Kulis… - Redox Biology, 2022 - Elsevier
Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to
different environmental stressors. We used a whole-body and tissue-specific phenotypic …

Identification of tumor‐associated macrophage subsets that are associated with breast cancer prognosis

E Strack, PA Rolfe, AF Fink, K Bankov… - Clinical and …, 2020 - Wiley Online Library
Background Breast cancer is the leading cause of cancer‐related deaths in women,
demanding new treatment options. With the advent of immune checkpoint blockade …