Talin and vinculin are part of a multicomponent system involved in mechanosensing in cell-
matrix adhesions. Both exist in autoinhibited forms, and activation of vinculin requires …

An important goal of biological research is to explain and hopefully predict cell behavior
from the molecular properties of cellular components. Accordingly, much work was done to …

Chromosomes with two centromeres provide a unique opportunity to study chromosome
breakage and DNA repair using completely endogenous cellular machinery. Using a …

One of the key structural proteins in the eukaryotic cell nucleus is lamin proteins. Lamins can
assemble into a quasi two dimensional protein meshwork at the nuclear periphery, referred …

The non-covalent biological bonds that constitute protein–protein or protein–ligand
interactions play crucial roles in many cellular functions, including mitosis, motility, and cell …

Transcription is the transfer of information stored in the DNA genome into RNA and an
essential process for cellular life. In all three domains of life, transcription is carried out by …