The Hierarchical Taxonomy of Psychopathology (HiTOP): A quantitative nosology based on consensus of evidence
Traditional diagnostic systems went beyond empirical evidence on the structure of mental
health. Consequently, these diagnoses do not depict psychopathology accurately, and their …
health. Consequently, these diagnoses do not depict psychopathology accurately, and their …
Transdiagnostic approaches to mental health problems: Current status and future directions.
T Dalgleish, M Black, D Johnston… - Journal of consulting and …, 2020 - psycnet.apa.org
Despite a longstanding and widespread influence of the diagnostic approach to mental ill
health, there is an emerging and growing consensus that such psychiatric nosologies may …
health, there is an emerging and growing consensus that such psychiatric nosologies may …
Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases
Genome-wide association studies of neurological diseases have identified thousands of
variants associated with disease phenotypes. However, most of these variants do not alter …
variants associated with disease phenotypes. However, most of these variants do not alter …
Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants
X Gao, T Geng, M Jiang, N Huang, Y Zheng… - Nature …, 2023 - nature.com
Abstract Theory predicts that biological processes of aging may contribute to poor mental
health in late life. To test this hypothesis, we evaluated prospective associations between …
health in late life. To test this hypothesis, we evaluated prospective associations between …
Genome-wide association study identifies 30 loci associated with bipolar disorder
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent …
association study (GWAS) including 20,352 cases and 31,358 controls of European descent …
Mendelian randomization analyses support causal relationships between brain imaging-derived phenotypes and risk of psychiatric disorders
Observational studies have reported the correlations between brain imaging-derived
phenotypes (IDPs) and psychiatric disorders; however, whether the relationships are causal …
phenotypes (IDPs) and psychiatric disorders; however, whether the relationships are causal …
Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis
We interrogate the joint genetic architecture of 11 major psychiatric disorders at
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …
biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four …
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Humans vary substantially in their willingness to take risks. In a combined sample of over 1
million individuals, we conducted genome-wide association studies (GWAS) of general risk …
million individuals, we conducted genome-wide association studies (GWAS) of general risk …
Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways
Depression is a polygenic trait that causes extensive periods of disability. Previous genetic
studies have identified common risk variants which have progressively increased in number …
studies have identified common risk variants which have progressively increased in number …