Abstract The cytoplasmic Ca 2+ concentration ([Ca 2+] cyt) regulates a vast number of
cellular functions, including insulin secretion from beta cells. The major physiological insulin …

The endoplasmic reticulum (ER) forms direct membrane contact sites with the plasma
membrane (PM) in eukaryotic cells. These ER-PM contact sites play essential roles in lipid …

Endoplasmic reticulum–plasma membrane contact sites (ER–PM CS) play fundamental
roles in all eukaryotic cells. Arabidopsis thaliana mutants lacking the ER–PM protein tether …

The endoplasmic reticulum (ER), which is composed of a continuous network of tubules and
sheets, forms the most widely distributed membrane system in eukaryotic cells. As a result, it …

Membrane contact sites (CSs) are specialized cellular regions where distinct organelles are
actively positioned very close to each other, at a distance of just a few nanometers …

Plant synaptotagmins (SYTs) are resident proteins of the endoplasmic reticulum (ER). They
are characterized by an N-terminal transmembrane region and C2 domains at the C …

The endoplasmic reticulum (ER) forms an extensive network of membrane contact sites with
intra-cellular organelles and the plasma membrane (PM). Interorganelle contacts have vital …

Close appositions between the endoplasmic reticulum (ER) and the plasma membrane (PM)
are a general feature of all cells and are abundant in neurons. A function of these …

Abstract The Synaptotagmin-like Mitochondrial-lipid-binding Protein (SMP) domain is a
newly identified lipid transfer module present in proteins that regulate lipid homeostasis at …

Background Non-coding genetic variants that influence gene transcription in pancreatic
islets play a major role in the susceptibility to type 2 diabetes (T2D), and likely also …