Cardiac fluid dynamics fundamentally involves interactions between complex blood flows
and the structural deformations of the muscular heart walls and the thin valve leaflets. There …

Myocardial supply changes to accommodate the variation of myocardial demand across the
heart wall to maintain normal cardiac function. A computational framework that couples the …

We consider parameter inference in cardio‐mechanic models of the left ventricle, in
particular the one based on the Holtzapfel‐Ogden (HO) constitutive law, using clinical in vivo …

Myocardial infarction (MI) produces acute changes in strain and stiffness within the infarct
that can affect remote areas of the left ventricle (LV) and drive pathological remodeling. We …

Introduction: Computational modeling of cardiac mechanics and hemodynamics in ischemic
heart disease (IHD) is important for a better understanding of the complex relations between …

Personalized computational cardiac models are considered to be a unique and powerful
tool in modern cardiology, integrating the knowledge of physiology, pathology and …

Introduction Finite element (FE) mechanics models of the heart are becoming more
sophisticated. However, there is lack of consensus about optimal element type and coupling …

Myocardial fibrosis progression and imbalanced redox state are closely associated with
increased extracellular matrix (ECM) stiffness. Candesartan (CAN), an angiotensin II (Ang II) …

Left ventricle myocardium has a complex micro-architecture, which was revealed to consist
of myocyte bundles arranged in a series of laminar sheetlets. Recent imaging studies …

The onset and progression of pathological heart conditions, such as cardiomyopathy or
heart failure, affect its mechanical behaviour due to the remodelling of the myocardial …