Early molecular markers for retrospective biodosimetry and prediction of acute health effects

M Abend, WF Blakely, P Ostheim… - Journal of …, 2022 - iopscience.iop.org
Radiation-induced biological changes occurring within hours and days after irradiation can
be potentially used for either exposure reconstruction (retrospective dosimetry) or the …

Transcriptomics for radiation biodosimetry: progress and challenges

SA Amundson - International journal of radiation biology, 2023 - Taylor & Francis
Purpose Transcriptomic-based approaches are being developed to meet the needs for large-
scale radiation dose and injury assessment and provide population triage following a …

Radiation type-and dose-specific transcriptional responses across healthy and diseased mammalian tissues

E Sagkrioti, GM Biz, I Takan, S Asfa, Z Nikitaki, V Zanni… - Antioxidants, 2022 - mdpi.com
Ionizing radiation (IR) is a genuine genotoxic agent and a major modality in cancer
treatment. IR disrupts DNA sequences and exerts mutagenic and/or cytotoxic properties that …

Gene expression for biodosimetry and effect prediction purposes: promises, pitfalls and future directions–key session ConRad 2021

P Ostheim, SA Amundson, C Badie… - … journal of radiation …, 2022 - Taylor & Francis
Purpose In a nuclear or radiological event, an early diagnostic or prognostic tool is needed
to distinguish unexposed from low-and highly exposed individuals with the latter requiring …

[HTML][HTML] Radiation-induced gene expression changes used for biodosimetry and clinical outcome prediction: challenges and promises

M Abend, P Ostheim, M Port - Cytogenetic and Genome Research, 2023 - karger.com
As the war in Ukraine progresses, the radiological and nuclear threat has never been as real
as now. The formation of life-threatening acute radiation syndrome (ARS), in particular after …

Validation of a high-throughput dicentric chromosome assay using complex radiation exposures

E Royba, M Repin, AS Balajee, I Shuryak… - Radiation …, 2023 - meridian.allenpress.com
Validation of biodosimetry assays is routinely performed using primarily orthovoltage
irradiators at a conventional dose rate of approximately 1 Gy/min. However …

The Influence of Computed Tomography Contrast Agent on Radiation-Induced Gene Expression and Double-Strand Breaks

S Schüle, F Bunert, C Hackenbroch… - Radiation …, 2024 - meridian.allenpress.com
After nuclear scenarios, combined injuries of acute radiation syndrome (ARS) with, eg,
abdominal trauma, will occur and may require contrast-enhanced computed tomography …

Whole-blood RNA biomarkers for predicting survival in non-human primates following thoracic radiation

MJ Aryankalayil, H Patel, JM May, U Shankavaram… - Scientific Reports, 2024 - nature.com
Radiation injury, either from radiotherapy or a mass-casualty event requires a health care
system that can efficiently allocate resources to patients. We conducted a comprehensive …

Effect of age and sex on gene expression-based radiation biodosimetry using mouse peripheral blood

CG Broustas, I Shuryak, AJ Duval… - Cytogenetic and genome …, 2023 - karger.com
Blood-based gene expression profiles that can reconstruct radiation exposure are being
developed as a practical approach to radiation biodosimetry. However, age and sex could …

International comparison exercise for biological dosimetry after exposures with neutrons performed at two irradiation facilities as part of the BALANCE project

D Endesfelder, U Kulka, M Bucher, U Giesen… - … and genome research, 2023 - karger.com
In the case of a radiological or nuclear event, biological dosimetry can be an important tool
to support clinical decision-making. During a nuclear event, individuals might be exposed to …