The molecular epidemiology of lung cancer

AG Schwartz, GM Prysak, CH Bock, ML Cote - Carcinogenesis, 2007 - academic.oup.com
Lung cancer is the leading cause of cancer mortality worldwide. There have been only slight
improvements in early diagnosis and survival, reflecting limited advances in screening and …

What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis?

G Fürstenberger, P Krieg… - … journal of cancer, 2006 - Wiley Online Library
Substantial evidence supports a functional role for cyclooxygenase‐and lipoxygenase‐
catalyzed arachidonic and linoleic acid metabolism in cancer development. Genetic …

Tumor infiltrating Foxp3+ regulatory T‐cells are associated with recurrence in pathologic stage I NSCLC patients

RP Petersen, MJ Campa, J Sperlazza, D Conlon… - Cancer, 2006 - Wiley Online Library
BACKGROUND. Early stage lung cancer has a variable prognosis, and there are currently
no markers that predict which patients will recur. This study examined the relation between …

Cyclo-oxygenase-2 and its inhibition in cancer: is there a role?

Z Liao, KA Mason, L Milas - Drugs, 2007 - Springer
Despite recent improvements in chemotherapy and radiation therapy in cancer management
with the addition of biological agents, novel treatment approaches are needed to further …

[HTML][HTML] Cyclooxygenase-2 expression as a predictor of outcome in colorectal carcinoma

J Al-Maghrabi, A Buhmeida, E Emam… - World journal of …, 2012 - ncbi.nlm.nih.gov
AIM: To correlate cyclooxygenase-2 (COX-2) expression profile with clinical and
pathological variables to assess their prognostic/predictive value in colorectal carcinoma …

[HTML][HTML] Prognostic value of COX-2 expression in patients with non-small cell lung cancer: a systematic review and meta-analysis

P Zhan, Q Qian, LK Yu - Journal of thoracic disease, 2013 - ncbi.nlm.nih.gov
Background Cyclooxygenase-2 (COX-2) has been implicated in tumorigenesis and
metastasis, and it presumably mediates the proliferation of endothelial cells and promotes …

EGFR and COX-2 protein expression in non-small cell lung cancer and the correlation with clinical features

F Li, Y Liu, H Chen, D Liao, Y Shen, F Xu… - Journal of Experimental & …, 2011 - Springer
Background To evaluate the expression of EGFR and COX-2 and their correlation with
prognosis in NSCLC Methods The paraffin embedded tumor samples of 50 NSCLC patients …

Prognostic impact of COX-2 in non-small cell lung cancer: a comprehensive compartment-specific evaluation of tumor and stromal cell expression

JSM Mattsson, B Bergman, M Grinberg, K Edlund… - Cancer letters, 2015 - Elsevier
Abstract Cyclooxygenase-2 (COX-2) is an enzyme that has been extensively investigated as
a prognostic marker in cancer. In non-small cell lung cancer (NSCLC) previous results …

Cox-2 in non-small cell lung cancer: a meta-analysis

H Jiang, J Wang, W Zhao - Clinica chimica acta, 2013 - Elsevier
BACKGROUND: We investigated the prognostic value of cyclooxygenase-2 (COX-2) for
survival of patients with non-small cell lung cancer (NSCLC). METHODS: We performed a …

Has Cox-2 a prognostic role in non-small-cell lung cancer? A systematic review of the literature with meta-analysis of the survival results

C Mascaux, B Martin, M Paesmans… - British journal of …, 2006 - nature.com
Abstract Cyclooxygenase-2 (COX-2) is overexpressed in lung cancer, especially in
adenocarcinoma (ADC). Our aim was to determine the prognostic value of COX-2 on …