Highlights•Search strategies of current protein–protein docking algorithms were
reviewed.•Challenges and future directions of established approaches were discussed.•Post …

Highlights•The development and trend of global protein–protein docking was briefly
reviewed.•18 global docking/scoring protocols were assessed on the latest docking …

Almost all critical functions in cells rely on specific protein–protein interactions.
Understanding these is therefore crucial in the investigation of biological systems. Despite …

Human endogenous retroviruses (HERVs) represent 8% of the human genome. HERV
products may represent tumor antigens relevant for cancer immunotherapy. We developed a …

Monkeypox is a self-limiting zoonotic viral disease and causes smallpox-like symptoms. The
disease has a case fatality ratio of 3–6% and, recently, a multi-country outbreak of the …

Small-angle X-ray scattering (SAXS) is an established technique that provides low-
resolution structural information on macromolecular solutions. Recent decades have …

Ligand-protein docking is one of the most common techniques used in virtual screening
campaigns. Despite the large number of docking software available, there is still the need of …

Background Modeling protein-protein interactions (PPIs) using docking algorithms is useful
for understanding biomolecular interactions and mechanisms. Typically, a docking algorithm …

Highlights•Computational docking methods can provide relevant structural data on protein
complexes.•Template-based docking and integrative modeling are currently the most …

Gastrointestinal diarrhea is majorly caused by the rotavirus (RV) in the children who
generally are under the age group of 5 years. WHO estimates that∼ 95% of the children …