Myopia: histology, clinical features, and potential implications for the etiology of axial elongation

JB Jonas, RA Jonas, MM Bikbov, YX Wang… - Progress in retinal and …, 2023 - Elsevier
Myopic axial elongation is associated with various non-pathological changes. These include
a decrease in photoreceptor cell and retinal pigment epithelium (RPE) cell density and …

IMI–Report on experimental models of emmetropization and myopia

D Troilo, EL Smith, DL Nickla, R Ashby… - … & visual science, 2019 - iovs.arvojournals.org
The results of many studies in a variety of species have significantly advanced our
understanding of the role of visual experience and the mechanisms of postnatal eye growth …

Scleral hypoxia is a target for myopia control

H Wu, W Chen, F Zhao, Q Zhou… - Proceedings of the …, 2018 - National Acad Sciences
Worldwide, myopia is the leading cause of visual impairment. It results from inappropriate
extension of the ocular axis and concomitant declines in scleral strength and thickness …

Homeostasis of eye growth and the question of myopia

J Wallman, J Winawer - Neuron, 2004 - cell.com
As with other organs, the eye's growth is regulated by homeostatic control mechanisms.
Unlike other organs, the eye relies on vision as a principal input to guide growth. In this …

The sclera and myopia

JAS Rada, S Shelton, TT Norton - Experimental eye research, 2006 - Elsevier
Myopia is a very common ocular problem, affecting perhaps one billion people worldwide.
Most myopia is produced by lengthening of the vitreous chamber of the ocular globe. High …

Effects of foveal ablation on emmetropization and form-deprivation myopia

EL Smith, R Ramamirtham… - … & visual science, 2007 - iovs.arvojournals.org
purpose. Because of the prominence of central vision in primates, it has generally been
assumed that signals from the fovea dominate refractive development. To test this …

Biomechanics of the sclera in myopia: extracellular and cellular factors

NA McBrien, AI Jobling, A Gentle - Optometry and vision science, 2009 - journals.lww.com
Purpose. Excessive axial elongation of the eye is the principal structural cause of myopia.
The increase in eye size results from active remodelling of the sclera, producing a …

Complex trait genetics of refractive error

TL Young, R Metlapally, AE Shay - Archives of ophthalmology, 2007 - jamanetwork.com
Refractive errors (myopia, hyperopia, and astigmatism) are complex heterogeneous
disorders of the human eye and are ideal for genetic investigation. Moderate to severe …

Myopia is associated with lower vitamin D status in young adults

S Yazar, AW Hewitt, LJ Black… - … & visual science, 2014 - iovs.arvojournals.org
Purpose.: To investigate the association between serum vitamin D levels and myopia in
young adults. Methods.: A total of 946 individuals participating in the 20-year follow-up of the …

Axial shortening in myopic children after repeated low-level red-light therapy: post hoc analysis of a randomized trial

W Wang, Y Jiang, Z Zhu, S Zhang, M Xuan… - Ophthalmology and …, 2023 - Springer
Introduction Axial length (AL) elongation in myopia is considered irreversible. We aimed to
systemically report unexpected AL shortening observed in a randomized clinical trial (RCT) …