The prion protein, PrPC, is a small, cell-surface glycoprotein notable primarily for its critical
role in pathogenesis of the neurodegenerative disorders known as prion diseases. A …

The essential role of the cellular prion protein (PrP C) in prion disorders such as Creutzfeldt–
Jakob disease is well documented. Moreover, evidence is accumulating that PrP C may act …

Biomolecular condensates formed via phase separation of proteins and nucleic acids are
thought to perform a wide range of critical cellular functions by maintaining spatiotemporal …

Although its involvement in prion replication and neurotoxicity during transmissible
spongiform encephalopathies is undisputed, the physiological role of the cellular prion …

Simple Summary Colorectal cancer (CRC) is a heterogeneous disease that can be divided
into 4 consensus molecular subtypes (CMS) according to molecular profiling. The CMS …

The cellular prion protein, PrP C, is a small, cell surface glycoprotein with a function that is
currently somewhat ill defined. It is also the key molecule involved in the family of …

Abstract Background Aberrant stress granules (SGs) are emerging as prime suspects in the
nucleation of toxic protein aggregates. Understanding the molecular networks linked with …

Misfolding of the prion protein is linked to multiple neurodegenerative diseases. A better
understanding of the process requires the identification and structural characterization of …

Simple Summary The cellular prion protein PrPC is best known for its involvement, under its
pathogenic isoform, in a group of neurodegenerative diseases. Notwithstanding, an …

In solid cancers, high expression of the cellular prion protein (PrPC) is associated with
stemness, invasiveness, and resistance to chemotherapy, but the role of PrPC in tumor …