Sensitivity to vaccines, therapeutic antibodies, and viral entry inhibitors and advances to counter the SARS-CoV-2 Omicron variant

H Zhou, M Møhlenberg, JC Thakor… - Clinical microbiology …, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) keeps evolving and
mutating into newer variants over time, which gain higher transmissibility, disease severity …

Mechanisms of antiviral immune evasion of SARS-CoV-2

DK Beyer, A Forero - Journal of molecular biology, 2022 - Elsevier
Abstract Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and is characterized by a delayed interferon (IFN) response …

SARS-CoV-2 Nsp5 demonstrates two distinct mechanisms targeting RIG-I and MAVS to evade the innate immune response

Y Liu, C Qin, Y Rao, C Ngo, JJ Feng, J Zhao, S Zhang… - MBio, 2021 - Am Soc Microbiol
Newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a
global pandemic with astonishing mortality and morbidity. The high replication and …

Coronaviruses Nsp5 antagonizes porcine gasdermin D-mediated pyroptosis by cleaving pore-forming p30 fragment

F Shi, Q Lv, T Wang, J Xu, W Xu, Y Shi, X Fu, T Yang… - MBio, 2022 - Am Soc Microbiol
Coronaviruses (CoVs) are a family of RNA viruses that typically cause respiratory, enteric,
and hepatic diseases in animals and humans. Here, we use porcine epidemic diarrhea virus …

Understanding individual SARS-CoV-2 proteins for targeted drug development against COVID-19

J van de Leemput, Z Han - Molecular and cellular biology, 2021 - Taylor & Francis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-
19 pandemic, responsible for millions of deaths globally. Even with effective vaccines, SARS …

SARS-CoV-2 main protease cleaves MAGED2 to antagonize host antiviral defense

X Ju, Z Wang, P Wang, W Ren, Y Yu, Y Yu, B Yuan… - Mbio, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent causing the
global pandemic of COVID-19. SARS-CoV-2 genome encodes a main protease (nsp5, also …

Activation of the NLRP1 inflammasome and its role in transmissible gastroenteritis coronavirus infection

H He, W Wang, L Li, X Zhang, H Shi, J Chen… - Journal of …, 2023 - Am Soc Microbiol
The inflammasome pathway is a critical early response mechanism of the host that detects
pathogens, initiates the production of inflammatory cytokines, and recruits effector cells to …

SARS-CoV-2 and oncolytic EV-D68-encoded proteases differentially regulate pyroptosis

S Shen, H Guo, Y Li, L Zhang, Y Tang, H Li… - Journal of …, 2024 - Am Soc Microbiol
Pyroptosis, a pro-inflammatory programmed cell death, has been implicated in the
pathogenesis of coronavirus disease 2019 and other viral diseases. Gasdermin family …

Enterovirus 3C protease cleaves TRIM7 to dampen its antiviral activity

W Fan, MB McDougal, JW Schoggins - Journal of virology, 2022 - Am Soc Microbiol
Mammalian TRIM7 is an antiviral protein that inhibits multiple human enteroviruses by
degrading the viral 2BC protein. Whether TRIM7 is reciprocally targeted by enteroviruses is …

PF-00835231 broadly inhibits swine Alpha-coronavirus, including emerging SADS-CoV

L Shi, Y Duan, L Cao, Y Zhang, C Yuan, M Sun… - Journal of …, 2024 - journals.asm.org
Swine Alpha-coronaviruses are one of the most destructive pathogens affecting the swine
industries across the world. Swine Alpha-coronaviruses include transmissible gastroenteritis …