What are the effects of PFAS exposure at environmentally relevant concentrations?

GM Sinclair, SM Long, OAH Jones - Chemosphere, 2020 - Elsevier
The group of synthetic chemicals known as poly and per-fluoroalkyl substances (PFAS) are
currently of high concern to environmental regulators and the public due to their widespread …

Toxicity effects of pesticides based on zebrafish (Danio rerio) models: Advances and perspectives

J Cui, S Tian, Y Gu, X Wu, L Wang, J Wang, X Chen… - Chemosphere, 2023 - Elsevier
Pesticides inevitably enter aquatic environments, posing potential risks to organisms. The
common aquatic model organism, zebrafish (Danio rerio), are widely used to evaluate the …

Development, characterization and comparisons of targeted and non-targeted metabolomics methods

A Ribbenstedt, H Ziarrusta, JP Benskin - PLoS One, 2018 - journals.plos.org
The potential of a metabolomics method to detect statistically significant perturbations in the
metabolome of an organism is enhanced by excellent analytical precision, unequivocal …

Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches

PD Noyes, KP Friedman, P Browne… - Environmental …, 2019 - ehp.niehs.nih.gov
Background: Extensive clinical and experimental research documents the potential for
chemical disruption of thyroid hormone (TH) signaling through multiple molecular targets …

Molecular mechanisms of developmental toxicity induced by graphene oxide at predicted environmental concentrations

X Zhang, Q Zhou, W Zou, X Hu - Environmental science & …, 2017 - ACS Publications
Developmental toxicity is a critical issue in nanotoxicity. However, very little is known about
the effects of graphene oxide (GO, a widely used carbon material) at predicted …

[HTML][HTML] A review of omics-based PFAS exposure studies reveals common biochemical response pathways

DJ Beale, GM Sinclair, R Shah, AM Paten… - Science of The Total …, 2022 - Elsevier
Abstract Per and Polyfluoroalkyl Substances (PFAS) are a diverse group of man-made
chemicals with a range of industrial applications and which are widespread in the …

Environmental metabolomics uncovers oxidative stress, amino acid dysregulation, and energy impairment in Daphnia magna with exposure to industrial effluents

LM Labine, EAO Pereira, S Kleywegt, KJ Jobst… - Environmental …, 2023 - Elsevier
Anthropogenic activities are regarded as point sources of pollution entering freshwater
bodies worldwide. With over 350,000 chemicals used in manufacturing, wastewater …

Assessing biological effects of fluoxetine in developing zebrafish embryos using gas chromatography-mass spectrometry based metabolomics

P Mishra, Z Gong, BC Kelly - Chemosphere, 2017 - Elsevier
Continuous low-dose exposure of pharmaceutically active compounds (PhACs) in aquatic
ecosystems is a concern worldwide. In this study, we utilized a gas chromatography mass …

Unravelling the mechanisms of PFOS toxicity by combining morphological and transcriptomic analyses in zebrafish embryos

R Martínez, L Navarro-Martín, C Luccarelli… - Science of the Total …, 2019 - Elsevier
Exposure to PFOS (perfluorooctanesulfonate) has been related to toxic effects on lipid
metabolism, immunological response, and different endocrine systems. We present here a …

Trends and perspectives in per-and polyfluorinated alkyl substances (PFASs) determination: Faster and broader

K Gao, Y Chen, Q Xue, J Fu, K Fu, J Fu, A Zhang… - TrAC Trends in …, 2020 - Elsevier
Per-and polyfluorinated alkyl substances (PFASs) have been in the spotlight due to their
pervasiveness, environmental persistence, bioaccumulation/magnification potential, and …