Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Most neurodegenerative diseases such as Alzheimer's disease, type 2 diabetes, Parkinson's
disease, etc. are caused by inclusions and plaques containing misfolded protein …

The aggregation and prion-like propagation of α-synuclein are involved in the pathogenesis
of Parkinson's disease. However, the underlying mechanisms regulating the assembly and …

Cognitive impairment occurs in most individuals with Parkinson's disease (PD), exacting a
high toll on patients, their caregivers, and the healthcare system. In this review, we begin by …

The tau protein (τ) is one of the two hallmark proteins of Alzheimer's disease (AD) together
with the amyloid β protein (Aβ). In contrast to Aβ, abnormally phosphorylated τ (p-τ) can also …

Tau is a microtubule-associated protein widely distributed in the central nervous system
(CNS). The main function of tau is to promote the assembly of microtubules and stabilize …

Concomitant Alzheimer's disease (AD) pathology is a frequent event in the context of Lewy
body disease (LBD), occurring in approximately half of all cases. Evidence shows that LBD …

Cognitive impairment is one of the most salient non-motor symptoms of Parkinson disease
(PD) that poses a significant burden on the patients and carers as well as being a risk factor …

The deposition of abnormal tau protein is characteristic of Alzheimer's disease (AD) and a
class of neurodegenerative diseases called tauopathies. Physiologically, tau maintains an …

Currently, there is a need for diagnostic markers in Lewy body disorders (LBD). α-synuclein
(αSyn) RT-QuIC has emerged as a promising assay to detect misfolded αSyn in clinically or …