Engineering synthetic biomolecular condensates

Y Dai, L You, A Chilkoti - Nature Reviews Bioengineering, 2023 - nature.com
The concept of phase-separation-mediated formation of biomolecular condensates provides
a new framework to understand cellular organization and cooperativity-dependent cellular …

Recent trends in protein and peptide-based biomaterials for advanced drug delivery

A Varanko, S Saha, A Chilkoti - Advanced drug delivery reviews, 2020 - Elsevier
Engineering protein and peptide-based materials for drug delivery applications has gained
momentum due to their biochemical and biophysical properties over synthetic materials …

Elastin-like polypeptides for biomedical applications

AK Varanko, JC Su, A Chilkoti - Annual review of biomedical …, 2020 - annualreviews.org
Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human
elastin. Their unique properties—including lower critical solution temperature phase …

Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs

Y Lin, SL Currie, MK Rosen - Journal of Biological Chemistry, 2017 - ASBMB
Liquid–liquid phase separation (LLPS) is thought to contribute to the establishment of many
biomolecular condensates, eukaryotic cell structures that concentrate diverse …

[HTML][HTML] Elastin-like polypeptides as models of intrinsically disordered proteins

S Roberts, M Dzuricky, A Chilkoti - FEBS letters, 2015 - Elsevier
Elastin-like polypeptides (ELPs) are a class of stimuli-responsive biopolymers inspired by
the intrinsically disordered domains of tropoelastin that are composed of repeats of the …

Elastin‐like polypeptides: biomedical applications of tunable biopolymers

SR MacEwan, A Chilkoti - Peptide Science: Original Research …, 2010 - Wiley Online Library
Artificial repetitive polypeptides have grown in popularity as a bioinspired alternative to
synthetic polymers. The genetically encoded synthesis, monodispersity, potential lack of …

Applications of elastin-like polypeptides in drug delivery

SR MacEwan, A Chilkoti - Journal of Controlled Release, 2014 - Elsevier
Elastin-like polypeptides (ELPs) are biopolymers inspired by human elastin. Their lower
critical solution temperature phase transition behavior and biocompatibility make them …

Effects of Hofmeister anions on the phase transition temperature of elastin-like polypeptides

Y Cho, Y Zhang, T Christensen, LB Sagle… - The Journal of …, 2008 - ACS Publications
The modulation of the lower critical solution temperature (LCST) of two elastin-like
polypeptides (ELPs) was investigated in the presence of 11 sodium salts that span the …

Peptide-based biopolymers in biomedicine and biotechnology

D Chow, ML Nunalee, DW Lim, AJ Simnick… - Materials Science and …, 2008 - Elsevier
Peptides are emerging as a new class of biomaterials due to their unique chemical,
physical, and biological properties. The development of peptide-based biomaterials is …

Opportunities for multicomponent hybrid hydrogels in biomedical applications

HK Lau, KL Kiick - Biomacromolecules, 2015 - ACS Publications
Hydrogels provide mechanical support and a hydrated environment that offer good
cytocompatibility and controlled release of molecules, and myriad hydrogels thus have been …